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YM17E

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Catalog No. T13373Cas No. 124900-72-7

YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.

YM17E

YM17E

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Purity: 99.29%
Catalog No. T13373Cas No. 124900-72-7
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$33In StockIn Stock
5 mg$53In StockIn Stock
10 mg$74In StockIn Stock
25 mg$128In StockIn Stock
50 mg$188In StockIn Stock
100 mg$280In StockIn Stock
1 mL x 10 mM (in DMSO)$71In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.29%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
Targets&IC50
ACAT (rabbit liver microsomes):44 nM
In vitro
YM17E is potent in inhibiting ACAT activity in the intestine with IC50 of 34 nM[1].
In vivo
YM17E inhibits the production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[1]. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E (oral; i.v.) produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats. YM17E (3, 10, 30 mg/kg; p.o.) decreases total cholesterol, cholesteryl ester, and non-HDL cholesterol in a dose-dependent manner. YM17E (oral) decreases total cholesterol and cholesteryl ester levels in the liver significantly in a dose-dependent manner[2].
Chemical Properties
Molecular Weight652.91
FormulaC40H56N6O2
Cas No.124900-72-7
SmilesCN(C)c1ccc(NC(=O)N(Cc2cccc(CN(C3CCCCCC3)C(=O)Nc3ccc(cc3)N(C)C)c2)C2CCCCCC2)cc1
Relative Density.1.16 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 12 mg/mL (18.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5316 mL7.6580 mL15.3160 mL76.5802 mL
5 mM0.3063 mL1.5316 mL3.0632 mL15.3160 mL
10 mM0.1532 mL0.7658 mL1.5316 mL7.6580 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YM-17EYM17Emono- acylglycerol acyltransferaseInhibitorinhibitDiglyceride acyltransferaseDiacylglycerol acyltransferaseAcyltransferaseacyl-CoA:cholesterol acyltransferaseACAT in rabbit liver microsomesACAT
Related Tags: buy YM17E | purchase YM17E | YM17E cost | order YM17E | YM17E chemical structure | YM17E in vivo | YM17E in vitro | YM17E formula | YM17E molecular weight
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