L-159282

Name: L-159282
Brand: TargetMol
SKU: T15680
Rating: 4.5 (1 reviews)

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Catalog No. T15680Cas No. 157263-00-8

Alias MK 996

L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity.

L-159282

😃Good

Catalog No. T15680Alias MK 996Cas No. 157263-00-8

L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,650	6-8 weeks	6-8 weeks
50 mg	$2,240	6-8 weeks	6-8 weeks
100 mg	$2,760	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity.
In vivo	L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without causing reflex tachycardia in aortic coarcted (high renin) rats. In anesthetized chimpanzees, L-159282 (1 mg/kg, iv) completely inhibits the AII pressor response and remains 52% active at 24 hours, decreasing blood pressure to levels comparable to losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1].
Synonyms	MK 996

Chemical Properties

Molecular Weight	524.63
Formula	C₃₀H₂₈N₄O₃S
Cas No.	157263-00-8
Smiles	O=C(NS(=O)(=O)C=1C=CC=CC1C2=CC=C(C=C2)CN3C4=NC(=CC(=C4N=C3CC)C)C)C=5C=CC=CC5
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc