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ALK-7 Protein, Human, Recombinant (GST)
(Synonyms: ALK-7, ALK7, ACVR1C, ACTR-IC, Activin receptor type-1C) Copy Product InfoSynonyms: ALK-7, ALK7, ACVR1C, ACTR-IC, Activin receptor type-1C
Catalog No. TMPC-00019 Copy Product Info
ALK-7 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q8NER5.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 μg | $953 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. |
| Description | ALK-7 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q8NER5. |
| Species | Human |
| Expression System | Baculovirus-Insect Cells |
| Tag | N-GST |
| Accession Number | Q8NER5 |
| Construction | Recombinant human ALK7 (135-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Protein Purity | >70% as determined by SDS-PAGE.  |
| Formulation | Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Synonyms | ALK-7, ALK7, ACVR1C, ACTR-IC, Activin receptor type-1C |
| Research Background | ALK-7, also known as ALK7 and ACVR1C, belongs to the ALK family. It is a type I receptor for the TGFB family of signaling molecules. TGF-β is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. ALK-7 is a serine-threonine kinase that can cause the activation of one of the SMAD signal transducers, SMAD2. ALK-7 has a ligand known as Nodal. Nodal stimulates the secretion of TIMP-1 and inhibits matrix metalloproteinases MMP-2 and MMP-9 activity. The overexpression of Nodal or constitutively active ALK-7 decreases cell migration and invasion, whereas knock-down of Nodal and ALK-7 has the opposite effects. |
| Molecular Weight | ~68 kDa |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: ALK-7 Protein, Human, Recombinant (GST) chemical structure | ALK-7 Protein, Human, Recombinant (GST) molecular weight
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