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Protein kinase inhibitors 1 hydrochloride
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Catalog No. T39860Cas No. 2321337-71-5
Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2, alongside a dissociation constant (Kd) of 9.5 nM for HIPK2.
Protein kinase inhibitors 1 hydrochloride
Copy Product Info😃Good
Catalog No. T39860Cas No. 2321337-71-5
Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2, alongside a dissociation constant (Kd) of 9.5 nM for HIPK2.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $82 | 5 days | 5 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2, alongside a dissociation constant (Kd) of 9.5 nM for HIPK2. |
| Targets&IC50 | HIPK1:136 nM (IC50), HIPK2:74 nM (IC50), HIPK2:9.5 nM (Kd) |
| In vitro | Protein kinase inhibitors 1 hydrochloride displays strong inhibitory action against HIPK2, with IC50 values of 136 nM and 74 nM for HIPK1 and HIPK2, respectively, and exhibits high affinity for HIPK2, as indicated by a Kd of 9.5 nM. This compound, also known as Compound A64, is ineffective as a Cdk1 inhibitor, with an IC50 exceeding 10 μM. A64 demonstrates moderate selectivity when tested against a range of kinases, showing Kd values ranging from 3.7 nM for PIM3 to 390 nM for ERK8, along with IC50 values of 19 nM for DYRK1A, 62 nM for DYRK1B, and 74 nM for HIPK2. |
| Molecular Weight | 419.88 |
| Formula | C18H18ClN5O3S |
| Cas No. | 2321337-71-5 |
| Smiles | Cl.O=C1NC(=O)\C(S1)=C/c1c[nH]c(=O)c(c1)-c1ccc(nc1)N1CCNCC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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