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LY-404187

Name: LY-404187
Brand: TargetMol
SKU: T7706
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7706Cas No. 211311-95-4

LY404187 is a positive allosteric modulator of AMPA receptors

LY-404187

😃Good

Purity: 99.34%

Catalog No. T7706Cas No. 211311-95-4

LY404187 is a positive allosteric modulator of AMPA receptors

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$167	In Stock	In Stock
50 mg	$251	In Stock	In Stock
100 mg	$357	In Stock	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	LY404187 is a positive allosteric modulator of AMPA receptors
Targets&IC50	GluR4i:0.21 µM (EC50), GluR2i:0.15 µM (EC50), GluR1i:5.65 µM (EC50), GluR3i:1.66 µM (EC50), GluR2o:1.44 µM (EC50)

Chemical Properties

Molecular Weight	342.46
Formula	C₁₉H₂₂N₂O₂S
Cas No.	211311-95-4
Smiles	CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Relative Density.	1.19 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (29.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9200 mL	14.6002 mL	29.2005 mL	146.0025 mL
5 mM	0.5840 mL	2.9200 mL	5.8401 mL	29.2005 mL
10 mM	0.2920 mL	1.4600 mL	2.9200 mL	14.6002 mL
20 mM	0.1460 mL	0.7300 mL	1.4600 mL	7.3001 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc