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LY-404187

Name: LY-404187
Brand: TargetMol
SKU: T7706
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7706Cas No. 211311-95-4

LY404187 is a positive allosteric modulator of AMPA receptors

LY-404187

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Purity: 99.34%

Catalog No. T7706Cas No. 211311-95-4

LY404187 is a positive allosteric modulator of AMPA receptors

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$167	In Stock	In Stock
50 mg	$251	In Stock	In Stock
100 mg	$357	In Stock	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.34%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

LY-404187 AI Summary

LY-404187 shows potentiation of responses mediated by 100 μM L-glutamate in HEK293 cells expressing human homomeric iGluR4 flip receptors, with an EC50 value of 290.0 nM. It exhibits bioactivity against human GLUR4 and GLUR2 flip and flop receptors, with EC50 values of 420.0 nM, 559.0 nM, 1061.0 nM, and 1905.0 nM, respectively. It acts as an agonist at AMPA and GluR2 receptors and inhibits GluR4, GluR3, GluR1, and GluR2 flop receptors at varying concentrations. The compound has a LogD7.4 of 3.5, indicating a moderate to high distribution coefficient. In viral assays, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 8.75% at 10 μM and in VERO-6 cells by 0.39% at the same concentration, and it inhibits the SARS-CoV-2 3CL-Pro protease by 12.55% at 20 μM. Additionally, LY-404187 shows inhibitory bioactivity on human HDAC6, with 23.94% inhibition in an enzymatic assay with a commercial peptide substrate, but a slight decrease (-2.41%) with a custom peptide substrate. Its effects on cell viability vary across different cell lines, showing both positive and negative growth rate changes depending on the tested cell type..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LY404187 is a positive allosteric modulator of AMPA receptors
Targets&IC50	GluR2i:0.15 µM (EC50), GluR4i:0.21 µM (EC50), GluR1i:5.65 µM (EC50), GluR3i:1.66 µM (EC50), GluR2o:1.44 µM (EC50)

Chemical Properties

Molecular Weight	342.46
Formula	C₁₉H₂₂N₂O₂S
Cas No.	211311-95-4
Smiles	CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)-c1ccc(cc1)C#N
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (29.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9200 mL	14.6002 mL	29.2005 mL	146.0025 mL
5 mM	0.5840 mL	2.9200 mL	5.8401 mL	29.2005 mL
10 mM	0.2920 mL	1.4600 mL	2.9200 mL	14.6002 mL
20 mM	0.1460 mL	0.7300 mL	1.4600 mL	7.3001 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc