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ACY-1083

Name: ACY-1083
Brand: TargetMol
SKU: T10244
Price: 155 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T10244 Copy Product Info

Purity: 99.43%

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ACY-1083 is a small molecule inhibitor, a highly selective HDAC6 inhibitor (IC50=3 nM), with 260-fold higher selectivity over other classes of HDAC isoforms. It is brain-penetrant and used for research on chemotherapy-induced peripheral neuropathy.

Cas No. 1708113-43-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$155	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$559	In Stock	In Stock
25 mg	$883	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
100 mg	$1,660	In Stock	In Stock
500 mg	$3,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.43%

Appearance:Solid

Color:White

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COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	ACY-1083 is a small molecule inhibitor, a highly selective HDAC6 inhibitor (IC50=3 nM), with 260-fold higher selectivity over other classes of HDAC isoforms. It is brain-penetrant and used for research on chemotherapy-induced peripheral neuropathy.
Targets & IC50	HDAC8:15.8 μM, HDAC9:19.3 μM, HDAC4:12.5 μM, HDAC5:4.17 μM, HDAC1:17.2 μM, HDAC6:3 nM, HDAC7:6.51 μM, HDAC2:70.7 μM
In vitro	Methods: Air-liquid interface cultures of bronchial epithelial cells derived from COPD patients were treated with 10 μM ACY-1083, and stimulated with TNF, TGF-β, cigarette smoke, or bacteria. Epithelial barrier function (TEER, FITC-dextran permeability), inflammatory factors (MSD, qPCR), morphology (AB/PAS staining), and ciliary function were detected. Results: ACY-1083 significantly reduced stimulus-induced permeability increase, decreased release of inflammatory factors such as IL-6 and CCL2, protected epithelial morphology and ciliary function, and maintained mucus clearance.[1]
In vivo	Methods: In adult male SD rat models, ACY-1083 (3 mg/kg) was administered orally to detect its reversal effect on paclitaxel-induced mechanical allodynia; in C57BL/6J mice, ACY-1083 (5 mg/kg) was administered via intraperitoneal injection for pharmacokinetic analysis, detecting blood drug concentration, half-life, and biologically effective plasma exposure time. Results: ACY-1083 reversed paclitaxel-induced mechanical allodynia. ACY-1083 exhibited a maximum blood concentration (Cmax) of 936 ng/mL, a half-life (T1/2) of 3.5 hours, and 8 hours of biologically effective plasma exposure time. [1] Methods: In C57BL/6J mouse models, ACY-1083 (10 mg/kg) was administered via intraperitoneal injection to detect its alleviating effect on cisplatin-induced mechanical allodynia. Results: ACY-1083 effectively alleviated cisplatin-induced mechanical allodynia. [2]

Chemical Properties

Molecular Weight	348.35
Formula	C₁₇H₁₈F₂N₄O₂
Cas No.	1708113-43-2
Smiles	ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 237.5 mg/mL (681.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8707 mL	14.3534 mL	28.7068 mL	143.5338 mL
5 mM	0.5741 mL	2.8707 mL	5.7414 mL	28.7068 mL
10 mM	0.2871 mL	1.4353 mL	2.8707 mL	14.3534 mL
20 mM	0.1435 mL	0.7177 mL	1.4353 mL	7.1767 mL
50 mM	0.0574 mL	0.2871 mL	0.5741 mL	2.8707 mL
100 mM	0.0287 mL	0.1435 mL	0.2871 mL	1.4353 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.