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ACY-1083

Name: ACY-1083
Brand: TargetMol
SKU: T10244
Price: 155 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10244Cas No. 1708113-43-2

ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.

ACY-1083

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Purity: 99.43%

Catalog No. T10244Cas No. 1708113-43-2

ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$155	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$559	In Stock	In Stock
25 mg	$883	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
100 mg	$1,660	In Stock	In Stock
500 mg	$3,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.43%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR FNMR

Product Introduction

Bioactivity

Description	ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.
Targets&IC50	HDAC9:19.3 μM, HDAC5:4.17 μM, HDAC6:3 nM, HDAC4:12.5 μM, HDAC1:17.2 μM, HDAC7:6.51 μM, HDAC2:70.7 μM, HDAC8:15.8 μM
In vitro	ACY-1083 (30 and 300 nM) dose-dependently improves cell viability[2].
In vivo	In C57BL/6J mice, ACY-1083 (10 mg/kg; i.p.) effectively relieves Cisplatin-induced mechanical allodynia. In adult male SD rats, ACY-1083 (3 mg/kg; orally) reverses Paclitaxel-induced mechanical allodynia. ACY-1083(5 mg/kg; i.p.) shows a Cmax of 936 ng/mL, a half-life (T1/2) of 3.5h, and a biologically active plasma exposure of 8 hours[1].

Chemical Properties

Molecular Weight	348.35
Formula	C₁₇H₁₈F₂N₄O₂
Cas No.	1708113-43-2
Smiles	ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 237.5 mg/mL (681.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8707 mL	14.3534 mL	28.7068 mL	143.5338 mL
5 mM	0.5741 mL	2.8707 mL	5.7414 mL	28.7068 mL
10 mM	0.2871 mL	1.4353 mL	2.8707 mL	14.3534 mL
20 mM	0.1435 mL	0.7177 mL	1.4353 mL	7.1767 mL
50 mM	0.0574 mL	0.2871 mL	0.5741 mL	2.8707 mL
100 mM	0.0287 mL	0.1435 mL	0.2871 mL	1.4353 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc