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ACY-1083

Name: ACY-1083
Brand: TargetMol
SKU: T10244
Price: 155 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10244Cas No. 1708113-43-2

ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.

ACY-1083

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Purity: 99.43%

Catalog No. T10244Cas No. 1708113-43-2

ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$155	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$559	In Stock	In Stock
25 mg	$883	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
100 mg	$1,660	In Stock	In Stock
500 mg	$3,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.43%

Resource Download

COA LCMS HNMR FNMR

Product Introduction

Bioactivity

Description	ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.
Targets&IC50	HDAC1:17.2 μM, HDAC8:15.8 μM, HDAC2:70.7 μM, HDAC6:3 nM, HDAC4:12.5 μM, HDAC7:6.51 μM, HDAC5:4.17 μM, HDAC9:19.3 μM
In vitro	ACY-1083 (30 and 300 nM) dose-dependently improves cell viability[2].
In vivo	In C57BL/6J mice, ACY-1083 (10 mg/kg; i.p.) effectively relieves Cisplatin-induced mechanical allodynia. In adult male SD rats, ACY-1083 (3 mg/kg; orally) reverses Paclitaxel-induced mechanical allodynia. ACY-1083(5 mg/kg; i.p.) shows a Cmax of 936 ng/mL, a half-life (T1/2) of 3.5h, and a biologically active plasma exposure of 8 hours[1].

Chemical Properties

Molecular Weight	348.35
Formula	C₁₇H₁₈F₂N₄O₂
Cas No.	1708113-43-2
Smiles	ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 237.5 mg/mL (681.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8707 mL	14.3534 mL	28.7068 mL	143.5338 mL
5 mM	0.5741 mL	2.8707 mL	5.7414 mL	28.7068 mL
10 mM	0.2871 mL	1.4353 mL	2.8707 mL	14.3534 mL
20 mM	0.1435 mL	0.7177 mL	1.4353 mL	7.1767 mL
50 mM	0.0574 mL	0.2871 mL	0.5741 mL	2.8707 mL
100 mM	0.0287 mL	0.1435 mL	0.2871 mL	1.4353 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc