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Triglycidyl isocyanurate

Name: Triglycidyl isocyanurate
Brand: TargetMol
SKU: T22443
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22443Cas No. 2451-62-9

Alias Tris(2,3-epoxypropyl) Isocyanurate, TGIC, TGI, Teroxirone

Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

Triglycidyl isocyanurate

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Purity: 99.01%

Catalog No. T22443Alias Tris(2,3-epoxypropyl) Isocyanurate, TGIC, TGI, TeroxironeCas No. 2451-62-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.01%

Appearance:solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
In vitro	Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].
In vivo	Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2-3 days for a total of seven doses over 30 days) suppresses xenograft tumor growth without affecting weight in nude mice[2].
Cell Research	Triglycidyl isocyanurate (0-30 μM; 48?hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres.
Animal Research	Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors[2].
Synonyms	Tris(2,3-epoxypropyl) Isocyanurate, TGIC, TGI, Teroxirone

Chemical Properties

Molecular Weight	297.26
Formula	C₁₂H₁₅N₃O₆
Cas No.	2451-62-9
Smiles	C(N1C(=O)N(CC2CO2)C(=O)N(CC3CO3)C1=O)C4CO4
Relative Density.	> 1.42 - <= 1.44 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (168.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3641 mL	16.8203 mL	33.6406 mL	168.2029 mL
5 mM	0.6728 mL	3.3641 mL	6.7281 mL	33.6406 mL
10 mM	0.3364 mL	1.6820 mL	3.3641 mL	16.8203 mL
20 mM	0.1682 mL	0.8410 mL	1.6820 mL	8.4101 mL
50 mM	0.0673 mL	0.3364 mL	0.6728 mL	3.3641 mL
100 mM	0.0336 mL	0.1682 mL	0.3364 mL	1.6820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc