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Sitagliptin phosphate monohydrate (Alias: MK-0431 phosphate monohydrate, MK-0431)

Name: Sitagliptin phosphate monohydrate
Brand: TargetMol
SKU: T0242L
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0242L Copy Product Info

Purity: 99.98%

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Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts.

Sitagliptin phosphate monohydrate

Copy Product Info

🥰Excellent

Catalog No. T0242L

Alias MK-0431 phosphate monohydrate, MK-0431

Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts.

Cas No. 654671-77-9

Pack Size	Price	USA Stock	Global Stock
50 mg	$37	-	In Stock
100 mg	$50	-	In Stock
500 mg	$108	-	In Stock
1 g	$152	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts.
Targets&IC50	DPP4:19 nM
In vitro	The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3]
Synonyms	MK-0431 phosphate monohydrate, MK-0431

Chemical Properties

Molecular Weight	523.33
Formula	C₁₆H₁₅F₆N₅O·H₃PO₄·H₂O
Cas No.	654671-77-9
Smiles	OP(O)(O)=O.N[C@H](CC1=C(C=C(C(F)=C1)F)F)CC(N2CCN3C(C2)=NN=C3C(F)(F)F)=O.O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 38 mg/mL (72.61 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (177.71 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9108 mL	9.5542 mL	19.1084 mL	95.5420 mL
5 mM	0.3822 mL	1.9108 mL	3.8217 mL	19.1084 mL
10 mM	0.1911 mL	0.9554 mL	1.9108 mL	9.5542 mL
20 mM	0.0955 mL	0.4777 mL	0.9554 mL	4.7771 mL
50 mM	0.0382 mL	0.1911 mL	0.3822 mL	1.9108 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0191 mL	0.0955 mL	0.1911 mL	0.9554 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MK0431 PhosphateMK0431MK 0431 PhosphateMK 0431DPP-4DPP4Dipeptidyl PeptidaseAutophagy

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