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Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts.
Catalog No. T0242LCas No. 654671-77-9
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Purity:99.65%
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Sitagliptin phosphate monohydrate

Catalog No. T0242LCas No. 654671-77-9

Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts.
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Pack SizePriceAvailabilityQuantity
100 mg$50In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts.
Targets&IC50
DPP4:19 nM
In vitro
The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3]
AliasMK-0431, MK-0431 phosphate monohydrate
Chemical Properties
Molecular Weight523.33
FormulaC16H15F6N5O·H3PO4·H2O
Cas No.654671-77-9
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 38 mg/mL (72.6 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (177.7 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.9108 mL9.5542 mL19.1084 mL95.5420 mL
5 mM0.3822 mL1.9108 mL3.8217 mL19.1084 mL
10 mM0.1911 mL0.9554 mL1.9108 mL9.5542 mL
20 mM0.0955 mL0.4777 mL0.9554 mL4.7771 mL
50 mM0.0382 mL0.1911 mL0.3822 mL1.9108 mL
DMSO
1mg5mg10mg50mg
100 mM0.0191 mL0.0955 mL0.1911 mL0.9554 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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