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Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA.[5] Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene.

FilterSignaling PathwaysMetabolismStearoyl-CoA Desaturase (SCD)
  • GSK1940029
    T54271150701-66-8In house
    GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor.
    • $30 TargetMol
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  • A939572
    T45151032229-33-6
    A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
    • $39
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    TargetMol | Citations Cited
  • PluriSIn 1
    T186991396-88-2
    PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.
    • $31
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    TargetMol | Citations Cited
  • Elemicin
    T3341487-11-6
    Elemicin (Elemicine) is a constituent of several plant species' essential oils with anticholinergic effects in human.
    • $41
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    TargetMol | Citations Cited
  • SLC13A5-IN-1
    T129312227548-95-8
    SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).
    • $43
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  • CAY10566
    T14878944808-88-2
    CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl
    • $47
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  • CVT-12012
    T64121018675-35-8
    CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
    • $34
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  • SCD1 inhibitor-4
    T105251295541-87-5
    SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
    • $44
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  • SSI-4
    T792621875084-68-6
    SSI-4 is a Stearoyl CoA desaturase 1 (SCD1) inhibitor that can be labeled with carbon-11 (11C) for use as a ligand in small animal in vivo PET/CT imaging studies of SCD1 [1].
    • $1,520
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  • MF-438
    T16068921605-87-0
    MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
    • $98
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  • XEN723
    T133561072803-08-7
    XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
    • $84
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    TargetMol | Inhibitor Sale
  • YTX-465
    T97222225824-53-1
    YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
    • $293
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  • MK-8245
    T26501030612-90-8
    MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
    • $33
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