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Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA.[5] Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene.

FilterHomeSignaling PathwaysMetabolismStearoyl-CoA Desaturase (SCD)
A939572
T45151032229-33-6
A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
  • $39
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CAY10566
T14878944808-88-2
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl
  • $47
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MK-8245
T26501030612-90-8
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
  • $33
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PluriSIn 1
T186991396-88-2
PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, highlighting a unique role for lipid metabolism in hPSCs.
  • $31
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MF-438
T16068921605-87-0
MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
  • $98
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Elemicin
T3341487-11-6
Elemicin (Elemicine) is a constituent of several plant species' essential oils with anticholinergic effects in human.
  • $41
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YTX-465
T97222225824-53-1
YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
  • $176
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GSK1940029
T54271150701-66-8In house
GSK1940029 (SCD inhibitor 1) is an inhibitor of stearoyl-CoA desaturase (SCD).
  • $30 TargetMol
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SCD1 inhibitor-4
T105251295541-87-5
SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
  • $38
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SLC13A5-IN-1
T129312227548-95-8
SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.
  • $43
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XEN723
T133561072803-08-7
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
  • $50
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CVT-12012
T64121018675-35-8
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
  • $34
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PFM046
T2042543053859-57-4
PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.
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10-14 weeks
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SSI-4
T792621875084-68-6
SSI-4 is a Stearoyl CoA desaturase 1 (SCD1) inhibitor that can be labeled with carbon-11 (11C) for use as a ligand in small animal in vivo PET CT imaging studies of SCD1 [1].
  • $1,520
6-8 weeks
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