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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(103)

Glyoxalase

(18)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(108)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(296)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(2)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(107)

Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA.[5] Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene.

Filter HomeSignaling PathwaysMetabolismStearoyl-CoA Desaturase (SCD)

A939572

T45151032229-33-6

A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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CAY10566

T14878944808-88-2

CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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MK-8245

T26501030612-90-8

MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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E6446

T42061219925-73-1

E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.

Stearoyl-CoA Desaturase (SCD)TLR

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SC-26196

T12856218136-59-5

SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 µM in a rat liver microsomal assay, with antiinflammatory properties.

Others Stearoyl-CoA Desaturase (SCD)

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Aramchol

C20-FABAC

T7294246529-22-6

Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner.

Others Stearoyl-CoA Desaturase (SCD)

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YTX-465

T97222225824-53-1

YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).

Stearoyl-CoA Desaturase (SCD)

$176

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T-3364366

T3364366, T 3364366

T289031356354-09-0

T-3364366 is an inhibitor of thienopyrimidinone delta-5 desaturase (Δ5D) with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively.

Others Stearoyl-CoA Desaturase (SCD)

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MF-438

T16068921605-87-0

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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PluriSIn 1

PluriSln 1, PluriSIn #1, NSC 14613

T186991396-88-2

PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, highlighting a unique role for lipid metabolism in hPSCs.

Apoptosis Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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Sesamin

Fsesamin

T2919607-80-7

Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia.

Others Stearoyl-CoA Desaturase (SCD)

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(-)-Asarinin

Sesamin, Pseudocubebin, Episesamin, Eleutheroside B4, Asarinin

T5S1959133-04-0

(-)-Asarinin (Eleutheroside B4) shows antibacterial activity.

Antibacterial Apoptosis ROS Src STAT Stearoyl-CoA Desaturase (SCD)

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GSK1940029

SCD inhibitor 1

T54271150701-66-8In house

GSK1940029 (SCD inhibitor 1) is an inhibitor of stearoyl-CoA desaturase (SCD).

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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MK-8245 analog

MK-8245-analog, MK 8245 analog

T209501030612-87-3

MK-8245 analog is an analog of MK-8245 which is a liver-targeted Inhibitor of Stearoyl-CoA Desaturase (SCD). It is useful for the Treatment of Dyslipidemia and Diabetes.

Others Stearoyl-CoA Desaturase (SCD)

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E6446 dihydrochloride

T40681345675-25-3

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

Stearoyl-CoA Desaturase (SCD)TLR

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SW209049

T98591673558-59-2In house

SW209049 is a stearoyl-CoA 9-desaturase inhibitor. SW209049 exhivits potent activity against H2122 cell with IC50 of 0.13uM.

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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CVT-11127

T90031018674-83-3

CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.

Apoptosis Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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SCD1 inhibitor-4

T105251295541-87-5

SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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SCD1 inhibitor-3

SCD1-IN-3, SCD1 inhibitor-3, SCD1 inhibitor 17a

T386831282606-48-7

SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety. SCD1 inhibitor-3 demonstrates strong potential for research in metabolic diseases, including obesity, type II diabetes, and dyslipidemia, as well as various skin conditions like acne and cancer.

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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SLC13A5-IN-1

T129312227548-95-8

SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.

Sodium Channel Stearoyl-CoA Desaturase (SCD)

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XEN723

T133561072803-08-7

XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).

Dehydrogenase Stearoyl-CoA Desaturase (SCD)

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CVT-12012

T64121018675-35-8

CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).

Stearoyl-CoA Desaturase (SCD)

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Elemicin

Elemicine, 3,4,5-trimethoxyallylbenzene

T3341487-11-6

Elemicin (Elemicine) is a constituent of several plant species' essential oils with anticholinergic effects in human.

5-HT Receptor Antibacterial Influenza Virus Stearoyl-CoA Desaturase (SCD)

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Sterculic acid

T41253738-87-4In house

Sterculic acid, a stearoyl-CoA desaturase-1 (SCD1) inhibitor, effectively suppresses delta-9 desaturase (Δ9D) activity in a dose-dependent manner, exhibiting an inhibition concentration (IC50) value of 0.9 μM [1].

Others Stearoyl-CoA Desaturase (SCD)

$1,880

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