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ADU-S100

Name: ADU-S100
Brand: TargetMol
SKU: T10252L3
Rating: 4.5 (1 reviews)

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Catalog No. T10252L3Cas No. 1638241-89-0

Alias ML RR-S2 CDA, MIW815

ADU-S100 (MIW815) is a cyclic dinucleotide (CDN) class STING agonist that significantly induces the production of IFN-β and pro-inflammatory cytokines TNF-α, IL-6, and MCP-1, induces TBK1 and IRF3 phosphorylation, and exhibits antitumour activity.

ADU-S100

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Purity: 99.83%

Catalog No. T10252L3Alias ML RR-S2 CDA, MIW815Cas No. 1638241-89-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$997	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	ADU-S100 (MIW815) is a cyclic dinucleotide (CDN) class STING agonist that significantly induces the production of IFN-β and pro-inflammatory cytokines TNF-α, IL-6, and MCP-1, induces TBK1 and IRF3 phosphorylation, and exhibits antitumour activity.
In vitro	Methods: DCs were treated with ADU-S100 (3.125, 6.25, 12.5, 25, 50, 100, 200 ng/mL) and activated to validate the activity of ADU-S100 and optimize the ideal dose for further assays. Results: The expression of co-stimulatory molecules CD40, CD86, and MHC II increased in a dose-dependent manner, indicating successful DC maturation. [4]
In vivo	Methods: SNI male and female mice were treated with ADU-S100 (35 nmol, intrathecal injection), and the expression of IFN-I and induced NF-κB genes in the dorsal horn tissue of mice treated with PBS or ADU-S100 after SNI was analyzed. Results: Transcripts of the proinflammatory cytokines IL-1β, TNFα, and CCL2 showed significant increases only in female mice treated with ADU-S100. [3]
Synonyms	ML RR-S2 CDA, MIW815

Chemical Properties

Molecular Weight	690.54
Formula	C₂₀H₂₄N₁₀O₁₀P₂S₂
Cas No.	1638241-89-0
Smiles	O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)OC1([H])CO[P@@](O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@](O2)(S)=O)(S)=O
Relative Density.	2.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16 mg/mL (23.17 mM), Sonication is recommended.

DMSO: 1 mg/mL (1.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4481 mL	7.2407 mL	14.4814 mL	72.4071 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.2896 mL	1.4481 mL	2.8963 mL	14.4814 mL
10 mM	0.1448 mL	0.7241 mL	1.4481 mL	7.2407 mL
20 mM	0.0724 mL	0.3620 mL	0.7241 mL	3.6204 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc