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ADU-S100

Name: ADU-S100
Brand: TargetMol
SKU: T10252L3
Price: 829 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10252L3Cas No. 1638241-89-0

Alias ML RR-S2 CDA, MIW815

ADU-S100 (MIW815) is a cyclic dinucleotide (CDN) class STING agonist that significantly induces the production of IFN-β and pro-inflammatory cytokines TNF-α, IL-6, and MCP-1, induces TBK1 and IRF3 phosphorylation, and exhibits antitumour activity.

ADU-S100

🥰Excellent

Purity: 99.83%

Catalog No. T10252L3Alias ML RR-S2 CDA, MIW815Cas No. 1638241-89-0

Pack Size	Price	Availability	Quantity
1 mg	$829	In Stock

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Purity:99.83%

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Product Introduction

Bioactivity

Description	ADU-S100 (MIW815) is a cyclic dinucleotide (CDN) class STING agonist that significantly induces the production of IFN-β and pro-inflammatory cytokines TNF-α, IL-6, and MCP-1, induces TBK1 and IRF3 phosphorylation, and exhibits antitumour activity.
In vitro	Methods: DCs were treated with ADU-S100 (3.125, 6.25, 12.5, 25, 50, 100, 200 ng/mL) and activated to validate the activity of ADU-S100 and optimize the ideal dose for further assays. Results: The expression of co-stimulatory molecules CD40, CD86, and MHC II increased in a dose-dependent manner, indicating successful DC maturation. [4]
In vivo	Methods: SNI male and female mice were treated with ADU-S100 (35 nmol, intrathecal injection), and the expression of IFN-I and induced NF-κB genes in the dorsal horn tissue of mice treated with PBS or ADU-S100 after SNI was analyzed. Results: Transcripts of the proinflammatory cytokines IL-1β, TNFα, and CCL2 showed significant increases only in female mice treated with ADU-S100. [3]
Synonyms	ML RR-S2 CDA, MIW815

Chemical Properties

Molecular Weight	690.54
Formula	C₂₀H₂₄N₁₀O₁₀P₂S₂
Cas No.	1638241-89-0
Smiles	O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)OC1([H])CO[P@@](O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@](O2)(S)=O)(S)=O
Relative Density.	2.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16 mg/mL (23.17 mM), Sonication is recommended.

DMSO: 1 mg/mL (1.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4481 mL	7.2407 mL	14.4814 mL	72.4071 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.2896 mL	1.4481 mL	2.8963 mL	14.4814 mL
10 mM	0.1448 mL	0.7241 mL	1.4481 mL	7.2407 mL
20 mM	0.0724 mL	0.3620 mL	0.7241 mL	3.6204 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc