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DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated
(Synonyms: ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262) Copy Product InfoSynonyms: ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262
Catalog No. TMPY-06835 Copy Product Info
DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.54 kDa and the accession number is NP_003833.4.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $215 | 7-10 days | 7-10 days | |
| 10 µg | $359 | 7-10 days | 7-10 days | |
| 20 µg | $600 | 7-10 days | 7-10 days | |
| 50 µg | $939 | 7-10 days | 7-10 days | |
| 100 µg | $1,580 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1.Loaded Biotinylated Recombinant Human DR5/TRAIL R2 Protein, His & Avi Tag (Cat#TMPY-06835) on SA Biosensor, can bind Recombinant Human TRAIL/TNFSF10 Protein with an affinity constant of 12.200 pM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 2.Immobilized Recombinant Human TNFSF10/TRAIL/APO-2L/CD253 Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human DR5/TRAIL R2 Protein (His & Avi Tag), Biotinylated (Cat#TMPY-06835), the EC50 is 0.5-2.0 ng/mL(QC tested). |
| Description | DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.54 kDa and the accession number is NP_003833.4. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His-Avi |
| Accession Number | NP_003833.4 |
| Construction | A DNA sequence encoding the Human TNFRSF10B (NP_003833.4) (Met1-Glu182) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. Predicted N terminal: Ile 56 |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262 |
| Research Background | Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 17.54 kDa (predicted); 21.65 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated chemical structure | DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated molecular weight
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