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Tenofovir
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Catalog No. T1649Cas No. 147127-20-6
Alias TDF, PMPA, GS 1278
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
Tenofovir
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Purity: 99.92%
Catalog No. T1649Alias TDF, PMPA, GS 1278Cas No. 147127-20-6
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $37 | In Stock | In Stock | |
| 10 mg | $50 | In Stock | In Stock | |
| 25 mg | $71 | In Stock | In Stock | |
| 50 mg | $95 | In Stock | In Stock | |
| 100 mg | $133 | In Stock | In Stock | |
| 500 mg | $336 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.92%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone. |
| In vitro | 4 μM Tenofovir completely inhibited the growth of HIVIIIB in MT-2 cells.Tenofovir inhibited hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir reduced the viral cytopathic effects of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) in MT-4 cells with EC50s of 1.15 μg/mL, 1.12 μg/mL, and 1.05 μg/mL.Tenofovir also reduced the viral cytopathic effects of SIV(mac251), SIV(B670), SHIV(89.6) and SHIV(89.6). Tenofovir also reduced the cytopathic effect of SIV(mac251),SIV(B670),SHIV(89.6) and SHIV(RTSHIV).Tenofovir showed unique activity against polynucleoside-resistant HIV expressing the Q151M mutation, and was less susceptible to viruses with the T69S insertion mutation. |
| In vivo | 4 μM Tenofovir completely inhibited the growth of HIVIIIB in MT-2 cells.Tenofovir inhibited hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir reduced the viral cytopathic effects of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) in MT-4 cells with EC50s of 1.15 μg/mL, 1.12 μg/mL, and 1.05 μg/mL.Tenofovir also reduced the viral cytopathic effects of SIV(mac251), SIV(B670), SHIV(89.6) and SHIV(89.6). Tenofovir also reduced the cytopathic effect of SIV(mac251),SIV(B670),SHIV(89.6) and SHIV(RTSHIV).Tenofovir showed unique activity against polynucleoside-resistant HIV expressing the Q151M mutation, and was less susceptible to viruses with the T69S insertion mutation. |
| Cell Research | Cells are plated into 48-well tissue culture plates (39,000 cells/mL) and allowed to grow for 48 h followed by treatment with vehicle or Tenofovir. Following the treatment period, cell viability is assessed using the MTT assay. The MTT assay relies on the conversion of tetrazolium dye 3-(4,5-dimethlthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to formazan by NAD(P)H-dependent oxidoreductases[1]. |
| Synonyms | TDF, PMPA, GS 1278 |
| Molecular Weight | 287.21 |
| Formula | C9H14N5O4P |
| Cas No. | 147127-20-6 |
| Smiles | C[C@H](CN1C=NC2=C1N=CN=C2N)OCP(O)(O)=O |
| Relative Density. | 1.79 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (13.93 mM), Heating is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 2 mg/mL (6.96 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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