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Rezatomidine
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Catalog No. T34308Cas No. 847829-38-3
Alias AGN-203818, AGN203818, AGN 203818
Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain.
Rezatomidine
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Purity: 98.34%
Catalog No. T34308Alias AGN-203818, AGN203818, AGN 203818Cas No. 847829-38-3
Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 2 mg | $293 | In Stock | In Stock | |
| 5 mg | $448 | In Stock | In Stock | |
| 10 mg | $658 | In Stock | In Stock | |
| 25 mg | $987 | In Stock | In Stock | |
| 50 mg | $1,380 | In Stock | In Stock | |
| 100 mg | $1,890 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.34%
Appearance:Solid
Color:White
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Product Introduction
Rezatomidine AI Summary
Rezatomidine shows moderate to high plasma protein binding affinity, with approximately 81.01% to 83.04% bound to rat and human plasma. It exhibits moderate intrinsic clearance in human liver microsomes and rat hepatocytes, with clearance rates of 24.55 mL·min^-1·g^-1 and 25.7 µL·min^-1·(10^6 cells)^-1, respectively. Additionally, the compound has a favorable distribution coefficient in the octan-1-ol/water (pH 7.4) system, with a LogD7.4 value of 2.9. In pharmacological studies, Rezatomidine shows a reduction in sulphrostone-induced tactile hypersensitivity in C57BL/6 mice when administered orally or intraperitoneally at 1 µg/kg, with an activity of 50.0%. It also induces sedation in the same mice when administered orally at higher doses of 100 to 1000 µg/kg, with an activity of less than 30.0%..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain. |
| Synonyms | AGN-203818, AGN203818, AGN 203818 |
| Molecular Weight | 232.34 |
| Formula | C13H16N2S |
| Cas No. | 847829-38-3 |
| Smiles | [C@H](C)(C1=C(C)C(C)=CC=C1)C2=CNC(=S)N2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (8.61 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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