Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2].
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Description | β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2]. |
In vitro | β-Catenin-IN-6 (compound 9) demonstrates inhibitory effects on LoVo and HT29 cells after a 24-hour exposure, with IC50 values of 1.4 μM and 1.37 μM, respectively. This compound exhibits growth inhibition in several human colorectal cancer cell lines [1]. |
In vivo | β-catenin-IN-6 (compound 9) exhibits poor bioavailability [1]. Administered intraperitoneally at a dose of 18.75 mg/kg daily for seven consecutive days, β-catenin-IN-6 reduces tumor volume in mice without affecting their body weight [1]. At a higher dosage of 150 mg/kg administered intraperitoneally once a week, β-catenin-IN-6 (compound 13) inhibits the growth of ectopic tumors in the β-catenin/RK3E mouse model [2]. |
Molecular Weight | 418.88 |
Formula | C22H19ClN6O |
CAS No. | 1039731-99-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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β-catenin-IN-6 1039731-99-1 inhibitor inhibit