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Thymidylate Kinase Inhibitor, YMU1

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Catalog No. T8864Cas No. 902589-96-2

YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site.

Thymidylate Kinase Inhibitor, YMU1

Thymidylate Kinase Inhibitor, YMU1

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Purity: 98.06%
Catalog No. T8864Cas No. 902589-96-2
YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$43In StockIn Stock
10 mg$68In StockIn Stock
25 mg$137In StockIn Stock
50 mg$220In StockIn Stock
100 mg$355In StockIn Stock
200 mg$495-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.06%
Appearance:Solid
Color:White
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Product Introduction

Thymidylate Kinase Inhibitor, YMU1 AI Summary
Thymidylate Kinase Inhibitor, YMU1 exhibits significant bioactivity, characterized by its cytotoxicity in IL-3-dependent mouse 32D cells expressing Bcr-Abl with an EC50 of 880 nM. It inhibits GST-tagged human TMPK expressed in Escherichia coli BL21 with an IC50 of 1650 nM and shows a 70% inhibition at a concentration of 2 µM. Additionally, it displays inhibitory activity against tyrosine kinase in protein samples from human MDA-MB-231 cells, though with an IC50 greater than 100,000 nM..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site.
Chemical Properties
Molecular Weight378.45
FormulaC17H22N4O4S
Cas No.902589-96-2
SmilesO=C1C=2C(SN1CC(=O)N3CCN(C(OCC)=O)CC3)=NC(C)=CC2C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mg/mL (13.21 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6424 mL13.2118 mL26.4236 mL132.1178 mL
5 mM0.5285 mL2.6424 mL5.2847 mL26.4236 mL
10 mM0.2642 mL1.3212 mL2.6424 mL13.2118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YMU-1YMU1YMU 1Thymidylate Kinase Inhibitor, YMU-1Thymidylate Kinase Inhibitor, YMU1InhibitorinhibithTMPK
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