DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-01751 Copy Product Info

DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.

DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-01751

Copy Product Info

DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.

Pack Size	Price	USA Stock	Global Stock
5 μg	$68	7-10 days	7-10 days
10 μg	$108	7-10 days	7-10 days
20 μg	$178	7-10 days	7-10 days
50 μg	$359	7-10 days	7-10 days
100 μg	$696	7-10 days	7-10 days
200 μg	$1,060	7-10 days	7-10 days
500 μg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Biological Activity	Loaded Recombinant Human TL1A/TNFSF15 Protein, His Tag, Biotinylated, (Cat#TMPY-07145) on SA Biosensor, can bind Recombinant Human DR3/TNFRSF25 Protein, hFc Tag (Cat#TMPY-01751) with an affinity constant of 2.57 μM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
Description	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q93038-10
Synonyms	WSL-LR,WSL-1,tumor necrosis factor receptor superfamily, member 25,TRAMP,TR3,TNFRSF12,LARD,DR3,DDR3,APO-3
Construction	A DNA sequence encoding the human TNFRSF25 (NP_683867.1) (Met1-Gln199) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Gln 25
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	45.9 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.