DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Loaded Recombinant Human TL1A/TNFSF15 Protein, His Tag, Biotinylated, (Cat#TMPY-07145) on SA Biosensor, can bind Recombinant Human DR3/TNFRSF25 Protein, hFc Tag (Cat#TMPY-01751) with an affinity constant of 2.57 μM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).

DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.

Human

HEK293 Cells

> 95 % as determined by SDS-PAGE.

Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.