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FKBP25/FKBP3 Protein, Human, Recombinant (His)

Catalog No. TMPJ-01068
Synonyms: 25 kDa FKBP, FKBP-3, Peptidyl-prolyl cis-trans isomerase FKBP3, FKBP25, FKBP-25, Immunophilin FKBP25, Rapamycin-selective 25 kDa immunophilin, PPIase FKBP3, 25 kDa FK506-binding protein, FK506-binding protein 3, Rotamase

FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FKBP25/FKBP3 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 60.00
50 μg 5 days $ 129.00
500 μg 5 days $ 806.00
1 mg 5 days $ 1,300.00
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Biological Description
Technical Params
Product Properties
Description FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Species Human
Expression System E. coli
Tag N-6His
Accession Number Q00688
Synonyms 25 kDa FKBP, FKBP-3, Peptidyl-prolyl cis-trans isomerase FKBP3, FKBP25, FKBP-25, Immunophilin FKBP25, Rapamycin-selective 25 kDa immunophilin, PPIase FKBP3, 25 kDa FK506-binding protein, FK506-binding protein 3, Rotamase
Amino Acid Met1-Asp224
Construction Recombinant Human 25 kDa FK506-binding Protein is produced by our E.coli expression system and the target gene encoding Met1-Asp224 is expressed with a 6His tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 30 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 8.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

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Keywords

FKBP25/FKBP3 Protein, Human, Recombinant (His) 25 kDa FKBP FKBP-3 Peptidyl-prolyl cis-trans isomerase FKBP3 FKBP25 FKBP-25 Immunophilin FKBP25 Rapamycin-selective 25 kDa immunophilin PPIase FKBP3 FKBP 3 FKBP3 FKBP 25 25 kDa FK506-binding protein FK506-binding protein 3 Rotamase recombinant recombinant-proteins proteins protein

 

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