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(Rac)-AMG8379

Name: (Rac)-AMG8379
Brand: TargetMol
SKU: T12655
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12655Cas No. 1641574-26-6

Alias (Rac)-AMG8380

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379, an orally active and selective sulfonamide NaV1.7 antagonist.

(Rac)-AMG8379

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Purity: 99.6%

Catalog No. T12655Alias (Rac)-AMG8380Cas No. 1641574-26-6

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379, an orally active and selective sulfonamide NaV1.7 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
2 mg	$293	In Stock	In Stock
5 mg	$448	In Stock	In Stock
10 mg	$658	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,380	In Stock	In Stock
100 mg	$1,890	-	In Stock
500 mg	$3,780	-	In Stock
1 mL x 10 mM (in DMSO)	$568	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

(Rac)-AMG8379 AI Summary

(Rac)-AMG8379 exhibits bioactivity as a selective sodium channel blocker, particularly inhibiting Nav1.7 channels with high potency. It has IC50 values ranging from 3.2 nM to 8.5 nM for human Nav1.7 channels in various assays, and 16.8 nM to 18.6 nM for mouse Nav1.7 channels. In contrast, it shows minimal activity against Nav1.5 channels with an IC50 greater than 30,000 nM, indicating strong selectivity for Nav1.7. Additionally, the compound shows high plasma protein binding in mice with a PPB of 99.83%. Furthermore, it has significantly higher selectivity indices in comparison to other sodium channel subtypes such as Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, and Nav1.6..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379, an orally active and selective sulfonamide NaV1.7 antagonist.
Targets&IC50	Nav1.7 (human):8.5 nM (IC50), Nav1.7 (mouse):18.6 nM (IC50)
Synonyms	(Rac)-AMG8380

Chemical Properties

Molecular Weight	543.93
Formula	C₂₅H₁₆ClF₂N₃O₅S
Cas No.	1641574-26-6
Smiles	O=C1N(C=2C(=CC(S(NC=3C=CON3)(=O)=O)=CC2)C=C1)C4=C(OC)C=C(C(F)=C4)C5=CC(Cl)=CC(F)=C5
Relative Density.	1.527 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (91.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8385 mL	9.1924 mL	18.3847 mL	91.9236 mL
5 mM	0.3677 mL	1.8385 mL	3.6769 mL	18.3847 mL
10 mM	0.1838 mL	0.9192 mL	1.8385 mL	9.1924 mL
20 mM	0.0919 mL	0.4596 mL	0.9192 mL	4.5962 mL
50 mM	0.0368 mL	0.1838 mL	0.3677 mL	1.8385 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc