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D-(-)-Mandelic acid (Alias: R-(−)-Mandelic Acid, Mandelic acid, D-(−)-Mandelic Acid, (R)-(-)-Mandelic acid)

Name: D-(-)-Mandelic acid
Brand: TargetMol
SKU: T2S0122
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T2S0122 Copy Product Info

Purity: 97.15%

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D-(-)-Mandelic acid ((R)-(-)-Mandelic acid) has the health function of killing sperm, reducing Yin, inhibiting bacteria, anti-inflammation and enhancing vagina self-cleaning.

D-(-)-Mandelic acid

Copy Product Info

🥰Excellent

Catalog No. T2S0122

Alias R-(−)-Mandelic Acid, Mandelic acid, D-(−)-Mandelic Acid, (R)-(-)-Mandelic acid

D-(-)-Mandelic acid ((R)-(-)-Mandelic acid) has the health function of killing sperm, reducing Yin, inhibiting bacteria, anti-inflammation and enhancing vagina self-cleaning.

Cas No. 611-71-2

Pack Size	Price	USA Stock	Global Stock	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:97.15%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

D-(-)-Mandelic acid AI Summary

D-(-)-Mandelic acid exhibits inhibitory activity against Yersinia Protein-tyrosine phosphatase 1B with an IC50 value of 5,500,000 nM. It also acts as an inhibitor of Mandelate racemase from Pseudomonas putida, with reported inhibition constants (Ki) of 590,000 nM and 810,000 nM at pH 7.5. The compound shows no significant bioactivity against HePTP, GAPDH, MKP-3, and in Ebola Virus entry assays, with IC50 values exceeding 100,000 nM and AC50 values at 44.67 µM and 44,668.4 nM, respectively. However, D-(-)-Mandelic acid demonstrates antiviral activity against SARS-CoV-2. It achieved 48.36% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, as well as a 14.61% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM, according to a FRET response assay. Additionally, it inhibited SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours with a 0.41% inhibition rate at 0.01 MOI of the virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-(-)-Mandelic acid ((R)-(-)-Mandelic acid) has the health function of killing sperm, reducing Yin, inhibiting bacteria, anti-inflammation and enhancing vagina self-cleaning.
Synonyms	R-(−)-Mandelic Acid, Mandelic acid, D-(−)-Mandelic Acid, (R)-(-)-Mandelic acid

Chemical Properties

Molecular Weight	152.15
Formula	C₈H₈O₃
Cas No.	611-71-2
Smiles	[C@@H](C(O)=O)(O)C1=CC=CC=C1
Relative Density.	1.321 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (328.62 mM), Sonication is recommended.

DMSO: 60 mg/mL (394.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5725 mL	32.8623 mL	65.7246 mL	328.6231 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL	65.7246 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL	32.8623 mL
20 mM	0.3286 mL	1.6431 mL	3.2862 mL	16.4312 mL
50 mM	0.1314 mL	0.6572 mL	1.3145 mL	6.5725 mL
100 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2862 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc