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PRRSV/CD163-IN-1

Name: PRRSV/CD163-IN-1
Brand: TargetMol
SKU: T72683
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72683 Copy Product Info

Purity: 98.65%

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PRRSV/CD163-IN-1 is an inhibitor targeting PRRSV and CD163 that blocks the interaction between PRRSV glycoproteins (GP2a, GP4) and the SRCR5 domain of CD163, suitable for research on porcine reproductive and respiratory syndrome (PRRS).

Cas No. 560995-89-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$117	-	In Stock
5 mg	$289	-	In Stock
10 mg	$479	-	In Stock
25 mg	$892	-	In Stock
50 mg	$1,380	-	In Stock
100 mg	$2,220	-	In Stock
1 mL x 10 mM (in DMSO)	$353	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.65%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Methods: In vitro protein-protein interaction assays were performed using 5 μM PRRSV/CD163-IN-1.
Results: It inhibited the protein-protein interaction (PPI) between PRRSV GP4 glycoprotein and the CD163-SRCR5 domain.
Methods: PAMs were treated with PRRSV/CD163-IN-1 for 24 h, and cytotoxicity was examined.
Results: Concentrations below 25 μM showed no obvious toxicity to PAMs, with an LC₅₀ of 81.7 μM [1].
Methods: PAMs were treated with 0, 5, 10, 15, 20 μM PRRSV/CD163-IN-1 for 4 h before PRRSV infection.
Results: It inhibited PRRSV infection of PAMs in a dose-dependent manner.
Methods: PAMs were treated with 15 μM PRRSV/CD163-IN-1 and infected with different genotypes of PRRSV.
Results: It significantly inhibited infection by both type Ⅰ and type Ⅱ PRRSV strains [1].

Chemical Properties

Molecular Weight	557.62
Formula	C₂₅H₂₄FN₅O₅S₂
Cas No.	560995-89-3
Smiles	O=S(=O)(NC1=NC=2C=CC=CC2N=C1NC3=CC=CC(=C3)S(=O)(=O)N4CCOCC4)C5=CC=C(F)C=C5C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (71.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7933 mL	8.9667 mL	17.9334 mL	89.6668 mL
5 mM	0.3587 mL	1.7933 mL	3.5867 mL	17.9334 mL
10 mM	0.1793 mL	0.8967 mL	1.7933 mL	8.9667 mL
20 mM	0.0897 mL	0.4483 mL	0.8967 mL	4.4833 mL
50 mM	0.0359 mL	0.1793 mL	0.3587 mL	1.7933 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: PRRSV/CD163-IN-1 chemical structure | PRRSV/CD163-IN-1 in vitro | PRRSV/CD163-IN-1 formula | PRRSV/CD163-IN-1 molecular weight