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KRAS inhibitor-37

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Catalog No. T201259Cas No. 3058573-95-5

KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.

KRAS inhibitor-37

KRAS inhibitor-37

😃Good
Catalog No. T201259Cas No. 3058573-95-5
KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mgInquiry3-6 months3-6 months
50 mgInquiry3-6 months3-6 months
100 mgInquiry3-6 months3-6 months
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.
Targets&IC50
KRas (G12C):0.019 nM (Kd), KRAS (WT):0.004 nM (Kd), KRAS (G12V):0.144 nM (Kd), KRas (G12D):0.041 nM (Kd)
Chemical Properties
Molecular Weight618.10
FormulaC32H33ClFN7O3
Cas No.3058573-95-5
SmilesFC=1C=2C3=C(N4[C@](COC3=NC1C=5C(=C(Cl)C=C6C5C=NN6)C7CC7)(COCCC4)[H])N=C(OC[C@@]89N(CC(=C)C8)CCC9)N2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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