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[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)

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Catalog No. TP3797Cas No. 2770688-04-3

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. This compound significantly reduces weight loss in diet-induced obesity (DIO) mouse models and improves Loperamide-induced urinary dysfunction in wild-type mice. It is applicable in the study of neurokinin receptor-mediated diseases such as obesity, insulin resistance, and type 2 diabetes.

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)

😃Good
Catalog No. TP3797Cas No. 2770688-04-3
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. This compound significantly reduces weight loss in diet-induced obesity (DIO) mouse models and improves Loperamide-induced urinary dysfunction in wild-type mice. It is applicable in the study of neurokinin receptor-mediated diseases such as obesity, insulin resistance, and type 2 diabetes.
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Product Introduction

Bioactivity
Description
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. This compound significantly reduces weight loss in diet-induced obesity (DIO) mouse models and improves Loperamide-induced urinary dysfunction in wild-type mice. It is applicable in the study of neurokinin receptor-mediated diseases such as obesity, insulin resistance, and type 2 diabetes.
Targets&IC50
NK2 (human):3.7 nM (EC50)
Chemical Properties
Molecular Weight819.99
FormulaC39H65N9O10
Cas No.2770688-04-3
Smiles[C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCCN)=O)C(N[C@H](C(NCC(N([C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)C)=O)=O)C(C)C)=O
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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