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SBI-0206965

Name: SBI-0206965
Brand: TargetMol
SKU: T2128
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2128Cas No. 1884220-36-3

Alias SBI0206965

SBI-0206965 is a potent, selective, and cell-permeable autophagy kinase ULK1 inhibitor with an IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.

SBI-0206965

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Purity: 99.13%

Catalog No. T2128Alias SBI0206965Cas No. 1884220-36-3

SBI-0206965 is a potent, selective, and cell-permeable autophagy kinase ULK1 inhibitor with an IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$61	In Stock
10 mg	$101	In Stock
25 mg	$177	In Stock
50 mg	$288	In Stock
100 mg	$448	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock

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Purity:99.13%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	SBI-0206965 is a potent, selective, and cell-permeable autophagy kinase ULK1 inhibitor with an IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
Targets&IC50	ULK1:108 nM, ULK2:711 nM
In vitro	In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death. [1]
Synonyms	SBI0206965

Chemical Properties

Molecular Weight	489.32
Formula	C₂₁H₂₁BrN₄O₅
Cas No.	1884220-36-3
Smiles	CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Relative Density.	1.434 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (112.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0437 mL	10.2183 mL	20.4365 mL	102.1826 mL
5 mM	0.4087 mL	2.0437 mL	4.0873 mL	20.4365 mL
10 mM	0.2044 mL	1.0218 mL	2.0437 mL	10.2183 mL
20 mM	0.1022 mL	0.5109 mL	1.0218 mL	5.1091 mL
50 mM	0.0409 mL	0.2044 mL	0.4087 mL	2.0437 mL
100 mM	0.0204 mL	0.1022 mL	0.2044 mL	1.0218 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc