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OSIP-486823

Name: OSIP-486823
Brand: TargetMol
SKU: T13807
Price: 469 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13807Cas No. 200803-37-8

Alias CP248

OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.

OSIP-486823

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Purity: 98.59%

Catalog No. T13807Alias CP248Cas No. 200803-37-8

OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$469	-	In Stock
5 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.59%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS FNMR

Product Introduction

Bioactivity

Description	OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.
Targets&IC50	SW48 cells:0.1 μM
In vitro	In SW480 human colon cancer cells, OSIP-486823 inhibits growth and induces apoptosis with an IC50 of 0.1 μM. OSIP-486823, a member of a new class of drugs known as selective apoptotic antineoplastic drugs targeting cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE), causes depolymerization of microtubules in interphase cells, inhibits spindle formation in mitotic cells, and induces multinucleated cells. Furthermore, OSIP-486823 disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells [1].
Synonyms	CP248

Chemical Properties

Molecular Weight	473.54
Formula	C₂₉H₂₈FNO₄
Cas No.	200803-37-8
Smiles	COc1cc(\C=C2\C(C)=C(CC(=O)NCc3ccccc3)c3cc(F)ccc23)cc(OC)c1OC
Relative Density.	1.206 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc