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Terpenoids

The terpenoids, sometimes called isoprenoids, are a large and diverse class of naturally occurring organic chemicals derived from terpenes. Most are multicyclic structures with oxygen-containing functional groups. About 60% of known natural products are terpenoids. Plant terpenoids are used for their aromatic qualities and play a role in traditional herbal remedies. Terpenoids contribute to the scent of eucalyptus, the flavors of cinnamon, cloves, and ginger, the yellow color in sunflowers, and the red color in tomatoes. Well-known terpenoids include citral, menthol, camphor, salvinorin A in the plant Salvia divinorum, the cannabinoids found in cannabis, ginkgolide and bilobalide found in Ginkgo biloba, and the curcuminoids found in turmeric and mustard seed. Many terpenes have biological activities and are used for the treatment of human diseases. The worldwide sales of terpene-based pharmaceuticals in 2002 were approximately US $12 billion. Among these pharmaceuticals, the anticancer drug Taxol and the antimalarial drug Artimesinin are two of the most renowned terpene-based drugs. All terpenoids are synthesized from two five-carbon building blocks. Based on the number of the building blocks, terpenoids are commonly classified as monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), and sesterterpenes (C25). These terpenoids display a wide range of biological activities against cancer, malaria, inflammation, and a variety of infectious diseases (viral and bacterial). In last two decades, natural-product bioprospecting from the marine environment has resulted in hundreds of terpenoids with novel structures and interesting bioactivities, with more to be discovered in the future. There is no doubt that more terpenoid-based clinical drugs will become available and will play a more significant role in human disease treatment in the near future.

  • TAXUSIN
    TN676319605-80-2
    Taxusin is a natural product form Taxus wallichiana.
    • $133
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  • Phorbol 12-myristate 13-acetate
    TQ019816561-29-8
    Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.
    • $44
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  • Abietic Acid
    T3090514-10-3
    Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin.
    • $83
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  • Specnuezhenide
    T380339011-92-2
    Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage.
    • $32
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  • Forskolin
    T293966575-29-9
    Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
    • $36
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  • Nuezhenidic acid
    TN1073183238-67-7
    Nuezhenidic acid is a natural product, posseses inhibitory activities against influenza A virus.
    • $263
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  • Bilobalide
    T280833570-04-6
    Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
    • $50
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  • Sweroside
    T6S225214215-86-2
    1. Sweroside possesses strong hepatoprotective effect. 2. Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.
    • $100
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  • Perillyl alcohol
    T3314536-59-4
    Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle.
    • $40
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  • 3,29-Dibenzoyl Rarounitriol
    T5S1028873001-54-8
    3,29-Dibenzoyl rarounitriol is the main active compound of the polychlorinated alkane triterpene esters in Trichosanthes kirilowii and can be used as a quantitative marker of Trichosanthes kirilowii.
    • $100
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  • CLINODISIDE A
    T3875916347-31-4
    Clinodiside A in rats with one compartment open model into the body, rapid distribution, elimination rate.
    • $50
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  • Hederagenin 28-O-beta-D-glucopyranosyl ester
    T3S020853931-25-2
    Hederagenin-28-beta-D-glucopyranoside, a triterpenoid saponin isolated from Ilex cornuta, protects against H2O2-induced damage in cardiomyocytes.
    • $130
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  • Hosenkoside K
    T5S2309160896-49-1
    Hosenkoside K is a glycoside isolated from the seeds of Crocus sativus.
    • $33
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  • Ursolic acid
    T072277-52-1
    Ursolic acid (Prunol)(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects.
    • $42
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  • Oridonin
    T279028957-04-2
    Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.
    • $45
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  • Dihydroartemisinin
    T060771939-50-9
    Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
    • $33
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  • Squalene
    T4749111-02-4
    Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All higher organisms produce squalene, including humans. Squalene is an intermediate product in the synthesis of cholesterol and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity.
    • $30
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  • 23-Hydroxybetulinic acid
    T3S215285999-40-2
    23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.
    • $82
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  • Diosbulbin B
    T4S079020086-06-0
    1. Diosbulbin B exhibits potential hepatotoxicity. 2. Diosbulbin B has potential anti-tumor effects which may be related to influencing the immune system for the first time.
    • $70
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  • Hederacoside C
    T337014216-03-6
    Hederacoside C (Hederasaponin C) is expectorant for Cold and cough relief, Bronchitis.
    • $42
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  • Aucubin
    T3416479-98-1
    Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
    • $97
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  • Rebaudioside C
    T336563550-99-2
    Dulcoside B (Rebaudioside C (Dulcoside B)) is a natural sweeteners used for diabetics and others on carbohydrate-controlled diets.
    • $82
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  • Ginkgolide B
    T275115291-77-7
    Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
    • $57
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  • Neryl acetate
    TCP2830141-12-8
    Neryl acetate (Acetic acid neryl ester) is used in perfumery and food flavouring.
    • $29
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  • Sclareol
    T3020515-03-7
    Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.
    • $30
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  • Cucurbitacin I
    TQ01962222-07-3
    Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
    • $77
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  • Citronellyl acetate
    T8057150-84-5
    Citronellyl acetate is a natural product
    • $29
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  • Sodium Aescinate
    T302720977-05-3
    Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.
    • $50
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  • DL-Menthol
    T297989-78-1
    DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.
    • $42
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  • Mudanpioside C
    T5S1649172760-03-1
    Mudanpioside C is isolated from the peony plant.
    • $97
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  • Nootkatone
    T3S01954674-50-4
    1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.
    • $40
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  • Carvacrol
    T4S1990499-75-2
    1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems.
    • $42
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  • α-Terpineol
    Fr1411598-55-5
    Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.
    • $31
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  • Paederoside
    T3S087220547-45-9
    1. Paederoside is a potent deterrent against the beetle was isolated from the aphid . 2. Paederoside displays high anti-tumor promoting activity against the Epstein-Barr virus activation.
    • $130
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  • Oleanolic Acid
    T2865508-02-1
    Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.
    • $33
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  • 1,4-Cineole
    TQ0001470-67-7
    1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
    • $41
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  • β-Carotene
    T16337235-40-7
    β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene inhibits free-radical damage to DNA.
    • $39
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  • Dipotassium glycyrrhizinate
    T566668797-35-3
    Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
    • $30
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  • Perillartine
    T2S199230950-27-7
    Perillartine (DL-Perillartine) is a sweetener. Perillartine activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.
    • $33
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  • Patchouli alcohol
    T29165986-55-0
    Patchouli alcohol (Patchoulol) is a sesquiterpene alcohol found in patchouli oil. It has antibacterial, antifungal, and antiviral actions. Patchouli alcohol also suppresses inflammation induced by lipopolysaccharide in vivo. Topical application of patchouli alcohol accelerates recovery from ultraviolet irradiation-induced skin damage through antioxidant and anti-inflammatory effects.
    • $50
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  • Tubeimoside I
    T2715102040-03-9
    Tubeimoside I (Tubeimoside-1)(Lobatoside-H) is an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM).
    • $50
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  • Ginsenoside Rb2
    T391911021-13-9
    Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.
    • $90
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  • Glaucocalyxin A
    T4S049879498-31-0
    1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.
    • $100
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  • Genipin 1-β-D-gentiobioside
    T4S229929307-60-6
    Genipin 1-β-D-gentiobioside is a natural product for research related to life sciences. The catalog number is T4S2299 and the CAS number is 29307-60-6.
    • $35
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  • Harpagide
    T6S20246926-08-5
    1. Harpagide has antibacterial activity. 2. Harpagide has antiviral activity. 3. Harpagide has anti-inflammatory activity.
    • $130
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  • α-Terpinene
    T790999-86-5
    α-Terpinene is a terpenoid,has acaricidal, antiprotozoal, and antioxidant properties
    • $41
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  • 7-Epi 10-desacetyl paclitaxel
    T573878454-17-8
    7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
    • $110
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  • Geraniol
    T5665106-24-1
    geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.
    • $46
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  • Protopine
    T3429130-86-9
    Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
    • $50
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  • Epifriedelanol
    T376816844-71-6
    Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary cells, it may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
    • $98
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