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Anti-DMP1 Antibody (6L12)
😃Good
Catalog No. TMAY-02147
Alias DMP-1, dentin matrix acidic phosphoprotein 1, ARHR, ARHP
Anti-DMP1 Antibody (6L12) is a Rabbit antibody targeting DMP1. Anti-DMP1 Antibody (6L12) can be used in ELISA.
Anti-DMP1 Antibody (6L12)
Anti-DMP1 Antibody (6L12)
😃Good
Catalog No. TMAY-02147Alias DMP-1, dentin matrix acidic phosphoprotein 1, ARHR, ARHP
Anti-DMP1 Antibody (6L12) is a Rabbit antibody targeting DMP1. Anti-DMP1 Antibody (6L12) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
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Chemical Properties
| Description | Anti-DMP1 Antibody (6L12) is a Rabbit antibody targeting DMP1. Anti-DMP1 Antibody (6L12) can be used in ELISA. |
| Alias | DMP-1, dentin matrix acidic phosphoprotein 1, ARHR, ARHP |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 6L12 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human DMP1 (rh DMP1; TMPY-02010; Q13316-1; Met1-Tyr513). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. DMP1 contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation, DMP1 becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. DMP1 may have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human DMP1 protein (TMPY-02010) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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