Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 196.00 | |
25 mg | In stock | $ 413.00 | |
50 mg | In stock | $ 615.00 | |
100 mg | In stock | $ 876.00 | |
500 mg | In stock | $ 1,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research. |
Targets&IC50 | LDHA:145.2 nM (IC50) |
In vitro |
LDHA-IN-3 (PSTMB) (0~500 μM; 48 h; MCF-7 cells) has cytotoxic effects.[1] PSTMB (0.01~1 μM) has a dose-dependent inhibitory effect on LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots.[1] PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage.[1] PSTMB efficiently binds to LDHA protein. PSTMB induces intrinsic pathway-mediated apoptosis in cancer cells through the production of mitochondrial ROS.[1] |
Synonyms | PSTMB, 1-(phenylseleno)-4-(trifluoromethyl) benzene |
Molecular Weight | 301.17 |
Formula | C13H9F3Se |
CAS No. | 227010-33-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30.11 mg/mL (100 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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LDHA-IN-3 227010-33-5 Metabolism Dehydrogenase PSTMB 1-(phenylseleno)-4-(trifluoromethyl) benzene LDHAIN3 LDHA IN 3 inhibitor inhibit