store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 363.00 | |
10 mg | In stock | $ 539.00 | |
25 mg | In stock | $ 873.00 | |
50 mg | In stock | $ 1,180.00 | |
100 mg | In stock | $ 1,620.00 |
Description | Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor. |
In vitro | POMHEX (78 nM, 8h) exhibits minimal impact on ENO1-WT glioma cells but significantly affects cells with ENO1 deletion[1]. POMHEX (0-720 nM) selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1-deleted glioma cells[1]. |
In vivo |
When administered intravenously or intraperitoneally at a dosage of 10 mg/kg (body weight) per day, POMHEX is well-tolerated without inducing hemolytic anemia. However, intravenous injection of POMHEX at 35 mg/kg causes lethargy and necessitates euthanasia by veterinarians[1]. POMHEX rapidly hydrolyzes to Hemi POMHEX in mouse plasma ex vivo, with a half-life of approximately 30 seconds, and in human blood ex vivo, the half-life is around 9 minutes[1]. |
Molecular Weight | 423.4 |
Formula | C17H30NO9P |
CAS No. | 2004714-34-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (118.09 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
POMHEX 2004714-34-3 Metabolism Glucokinase inhibitor inhibit