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POMHEX

Name: POMHEX
Brand: TargetMol
SKU: T36491
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T36491Cas No. 2004714-34-3

Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor.

POMHEX

🥰Excellent

Purity: 99.28%

Catalog No. T36491Cas No. 2004714-34-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$148	In Stock	In Stock
5 mg	$363	In Stock	In Stock
10 mg	$539	In Stock	In Stock
25 mg	$873	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,620	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.28%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor.
In vitro	POMHEX (78 nM, 8h) exhibits minimal impact on ENO1-WT glioma cells but significantly affects cells with ENO1 deletion[1]. POMHEX (0-720 nM) selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1-deleted glioma cells[1].
In vivo	When administered intravenously or intraperitoneally at a dosage of 10 mg/kg (body weight) per day, POMHEX is well-tolerated without inducing hemolytic anemia. However, intravenous injection of POMHEX at 35 mg/kg causes lethargy and necessitates euthanasia by veterinarians[1]. POMHEX rapidly hydrolyzes to Hemi POMHEX in mouse plasma ex vivo, with a half-life of approximately 30 seconds, and in human blood ex vivo, the half-life is around 9 minutes[1].

Chemical Properties

Molecular Weight	423.4
Formula	C₁₇H₃₀NO₉P
Cas No.	2004714-34-3
Smiles	O=C(OCOP(=O)(OCOC(=O)C(C)(C)C)C1C(=O)N(O)CCC1)C(C)(C)C
Relative Density.	1.26 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3618 mL	11.8092 mL	23.6183 mL	118.0916 mL
5 mM	0.4724 mL	2.3618 mL	4.7237 mL	23.6183 mL
10 mM	0.2362 mL	1.1809 mL	2.3618 mL	11.8092 mL
20 mM	0.1181 mL	0.5905 mL	1.1809 mL	5.9046 mL
50 mM	0.0472 mL	0.2362 mL	0.4724 mL	2.3618 mL
100 mM	0.0236 mL	0.1181 mL	0.2362 mL	1.1809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc