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IRAK1-IN-1

🥰Excellent
Catalog No. T210102

IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. It suppresses IL-6 release in murine J774A cells and human THP-1 cells, with IC50 values of 4.57 μM and 6.51 μM, respectively. Additionally, IRAK1-IN-1 alleviates LPS-induced acute lung injury and DSS-induced colitis in mice.

IRAK1-IN-1

IRAK1-IN-1

🥰Excellent
Catalog No. T210102
IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. It suppresses IL-6 release in murine J774A cells and human THP-1 cells, with IC50 values of 4.57 μM and 6.51 μM, respectively. Additionally, IRAK1-IN-1 alleviates LPS-induced acute lung injury and DSS-induced colitis in mice.
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Product Introduction

Bioactivity
Description
IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. It suppresses IL-6 release in murine J774A cells and human THP-1 cells, with IC50 values of 4.57 μM and 6.51 μM, respectively. Additionally, IRAK1-IN-1 alleviates LPS-induced acute lung injury and DSS-induced colitis in mice.
Chemical Properties
FormulaC17H20N2O4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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