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CP-31398 dihydrochloride

🥰Excellent
Catalog No. T21648Cas No. 1217195-61-3
Alias CP 31398 dihydrochloride

CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

CP-31398 dihydrochloride
Other Forms of CP-31398 dihydrochloride:
CP-31398T201533259199-65-0
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CP-31398 dihydrochloride

🥰Excellent
Purity: 98.23%
Catalog No. T21648Alias CP 31398 dihydrochlorideCas No. 1217195-61-3
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$30In StockIn Stock
10 mg$48In StockIn Stock
25 mg$95In StockIn Stock
50 mg$153In StockIn Stock
100 mg$248In StockIn Stock
1 mL x 10 mM (in DMSO)$37In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.23%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
In vitro
CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells[1]. CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells[2].
SynonymsCP 31398 dihydrochloride
Chemical Properties
Molecular Weight435.4
FormulaC22H28Cl2N4O
Cas No.1217195-61-3
SmilesCl.Cl.COc1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 6 mg/mL (13.78 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.3 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2967 mL11.4837 mL22.9674 mL114.8369 mL
5 mM0.4593 mL2.2967 mL4.5935 mL22.9674 mL
10 mM0.2297 mL1.1484 mL2.2967 mL11.4837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p53MDM-2/p53InhibitorinhibitCP-31398 DihydrochlorideCP31398 dihydrochlorideCP31398 DihydrochlorideCP-31398CP31398CP 31398 DihydrochlorideCP 31398
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