Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and an ATP analogue. It exhibits cytotoxicity towards multiple myeloma cells, with an IC50 of 23.1 μM.
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Description | 8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and an ATP analogue. It exhibits cytotoxicity towards multiple myeloma cells, with an IC50 of 23.1 μM. |
In vitro | Treatment with 8-Bromo-ATP (10-50 μM; 5 days) demonstrates cytotoxic effects on multiple myeloma cells (MM 1.s) as evidenced by decreased cell viability. This compound facilitates fluorescence measurements by selectively quenching specific tryptophan residues in ATPase, thereby enabling more precise analysis. Moreover, 8-Bromo-ATP significantly amplifies the dephosphorylation rate of native ATPase by 2-3 times, in the absence of divalent cations, underscoring its potential utility in biochemical research and therapeutic applications targeting ATPase-related functions. |
Synonyms | 8-Bromoadenosine 5'-triphosphate, 8-Bromo-ATP, 8-Br-ATP |
Molecular Weight | 586.077 |
Formula | C10H15BrN5O13P3 |
CAS No. | 23567-97-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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8-Bromo-ATP 23567-97-7 8 Bromo ATP 8-Bromoadenosine 5'-triphosphate 8BromoATP 8-Br-ATP inhibitor inhibit