8-Bromo-ATP

Name: 8-Bromo-ATP
Brand: TargetMol
SKU: T39891
Rating: 4.5 (1 reviews)

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Catalog No. T39891Cas No. 23567-97-7

Alias 8-Bromo-ATP, 8-Bromoadenosine 5'-triphosphate, 8-Br-ATP

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and ATP analogue that exhibits cytotoxicity towards multiple myeloma cells, with an IC50 of 23.1 μM.

8-Bromo-ATP

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Catalog No. T39891Alias 8-Bromo-ATP, 8-Bromoadenosine 5'-triphosphate, 8-Br-ATPCas No. 23567-97-7

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and ATP analogue that exhibits cytotoxicity towards multiple myeloma cells, with an IC50 of 23.1 μM.

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Product Introduction

Bioactivity

Description	8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and ATP analogue that exhibits cytotoxicity towards multiple myeloma cells, with an IC50 of 23.1 μM.
In vitro	Treatment with 8-Bromo-ATP (10-50 μM; 5 days) demonstrates cytotoxic effects on multiple myeloma cells (MM 1.s) as evidenced by decreased cell viability. This compound facilitates fluorescence measurements by selectively quenching specific tryptophan residues in ATPase, thereby enabling more precise analysis. Moreover, 8-Bromo-ATP significantly amplifies the dephosphorylation rate of native ATPase by 2-3 times, in the absence of divalent cations, underscoring its potential utility in biochemical research and therapeutic applications targeting ATPase-related functions.
Synonyms	8-Bromo-ATP, 8-Bromoadenosine 5'-triphosphate, 8-Br-ATP

Chemical Properties

Molecular Weight	586.077
Formula	C₁₀H₁₅BrN₅O₁₃P₃
Cas No.	23567-97-7
Smiles	Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(Br)nc12

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

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Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

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