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NIK-IN-3
Catalog No. T214304 Copy Product Info
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NIK-IN-3 is a potent, orally active inhibitor of NF-κB-inducing kinase (NIK) with an IC50 value of 5.2 nM. It effectively suppresses activation of the non-canonical NF-κB pathway and inhibits the secretion of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and the chemokine CXCL12. NIK-IN-3 demonstrates significant anti-inflammatory effects in LPS-induced sepsis and DSS-induced colitis mouse models. This compound is applicable in inflammation-related research, such as studies on colitis.
NIK-IN-3
Copy Product Info🥰Excellent
Catalog No. T214304
NIK-IN-3 is a potent, orally active inhibitor of NF-κB-inducing kinase (NIK) with an IC50 value of 5.2 nM. It effectively suppresses activation of the non-canonical NF-κB pathway and inhibits the secretion of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and the chemokine CXCL12. NIK-IN-3 demonstrates significant anti-inflammatory effects in LPS-induced sepsis and DSS-induced colitis mouse models. This compound is applicable in inflammation-related research, such as studies on colitis.
NIK-IN-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | NIK-IN-3 is a potent, orally active inhibitor of NF-κB-inducing kinase (NIK) with an IC50 value of 5.2 nM. It effectively suppresses activation of the non-canonical NF-κB pathway and inhibits the secretion of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and the chemokine CXCL12. NIK-IN-3 demonstrates significant anti-inflammatory effects in LPS-induced sepsis and DSS-induced colitis mouse models. This compound is applicable in inflammation-related research, such as studies on colitis. |
| Targets&IC50 | NF-κB:5.2 nM |
| In vitro | NIK-IN-3 (Compound 38) effectively inhibits the activation of the non-canonical NF-κB pathway in HEK293 cells at concentrations between 1-5 μM. At 100 nM over 3 days, it suppresses Th17 cell differentiation in murine naive CD4+ T cells without significant cytotoxicity. Additionally, at 5 μM for 22 hours, NIK-IN-3 inhibits the secretion of inflammatory factors such as TNF-α, IL-6, IL-1β, and CXCL12 in LPS and CD40-induced RAW264.7 cells. |
| In vivo | NIK-IN-3 (Compound 38) administered intraperitoneally at 10 mg/kg enhances survival rates and decreases inflammation in mice models of LPS-induced sepsis by inhibiting the non-canonical NF-κB pathway. Additionally, oral administration of NIK-IN-3 at 25-50 mg/kg once daily for 7 days alleviates colitis symptoms in C57BL/6 mice (DSS-induced colitis model). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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