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Graveoline

Name: Graveoline
Brand: TargetMol
SKU: TN6705
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6705Cas No. 485-61-0

Alias Foliosine, 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one

Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells

Graveoline

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Purity: 98.14%

Catalog No. TN6705Alias Foliosine, 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-oneCas No. 485-61-0

Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.14%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells
In vitro	Results of MTT assay revealed that, in case of A375 cells,the cell viability gradually decreased upon administration of minimal concentration to the higher ones of graveoline. Upon treatment with 22.23 ± 0.79 μg/mL of graveoline,the cell viability reduced to 50%[1] .
Synonyms	Foliosine, 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one

Chemical Properties

Molecular Weight	279.29
Formula	C₁₇H₁₃NO₃
Cas No.	485-61-0
Smiles	Cn1c(cc(=O)c2ccccc12)-c1ccc2OCOc2c1
Relative Density.	1.327 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.2 mg/mL (18.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5805 mL	17.9025 mL	35.8051 mL	179.0254 mL
5 mM	0.7161 mL	3.5805 mL	7.1610 mL	35.8051 mL
10 mM	0.3581 mL	1.7903 mL	3.5805 mL	17.9025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc