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MPI_5a

Name: MPI_5a
Brand: TargetMol
SKU: T16129
Price: 278 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16129Cas No. 1259296-46-2

MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).

MPI_5a

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Purity: 99.62%

Catalog No. T16129Cas No. 1259296-46-2

MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$278	In Stock	In Stock
2 mg	$445	In Stock	In Stock
5 mg	$838	In Stock	In Stock
10 mg	$1,130	In Stock	In Stock
25 mg	$1,670	In Stock	In Stock
50 mg	$2,260	In Stock	In Stock
100 mg	$2,970	-	In Stock
1 mL x 10 mM (in DMSO)	$722	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.62%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

MPI_5a AI Summary

MPI_5a exhibits significant bioactivity as a histone deacetylase (HDAC) inhibitor, showing potent inhibition particularly towards HDAC6. In human HeLa cells, the compound has an IC50 value of 210.0 nM and reduces K40 hyperacetylation of alpha-tubulin. It demonstrates a high selectivity ratio of 500.0 when comparing the IC50 values for HDAC1/HDAC2 to HDAC6, and a selectivity ratio of 40.0 favoring HDAC8 over HDAC6. Despite this, the compound shows minimal inhibitory effects on other HDAC isoforms such as HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC10, and HDAC11, with IC50 values for these isoforms exceeding 10,000 nM. The compound also demonstrates low permeability in human Caco2 cells and high thermodynamic solubility in phosphate buffer, while showing no significant inhibitory activity against matrix metalloproteinases (MMPs)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).
Targets&IC50	HDAC6:36 nM

Chemical Properties

Molecular Weight	299.32
Formula	C₁₆H₁₇N₃O₃
Cas No.	1259296-46-2
Smiles	C(=O)(N1CC=2C(=CC(C(NO)=O)=CC2)CC1)C=3N(C)C=CC3
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (826.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3409 mL	16.7045 mL	33.4091 mL	167.0453 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL	33.4091 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL	16.7045 mL
20 mM	0.1670 mL	0.8352 mL	1.6705 mL	8.3523 mL
50 mM	0.0668 mL	0.3341 mL	0.6682 mL	3.3409 mL
100 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc