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Tegobuvir

Name: Tegobuvir
Brand: TargetMol
SKU: T17029
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17029Cas No. 1000787-75-6

Alias GS-9190, GS 333126

Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.

Tegobuvir

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Purity: 99.21%

Catalog No. T17029Alias GS-9190, GS 333126Cas No. 1000787-75-6

Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$559	In Stock	In Stock
50 mg	$790	In Stock	In Stock
100 mg	$1,090	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$225	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.21%

Appearance:solid

Color:White

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COA HNMR LCMS

Product Introduction

Tegobuvir AI Summary

Tegobuvir exhibits notable antiviral activity and enzyme inhibition properties. Specifically, it demonstrates potent antiviral efficacy against Hepatitis C virus (HCV) genotype 1b in human HuH5.2 cells with an EC50 of 0.7 nM after 72 hours, as assessed via a luciferase reporter gene assay. Additionally, it shows antiviral activity against HCV genotype 1b in human HuH7 cells with an EC50 of 5.0 nM after 48 hours and inhibits HCV genotype 1b NS5B RNA-dependent-RNA polymerase with an EC50 of approximately 2.908-2.9 nM. The compound also exhibits inhibitory effects on human ERG expressed in CHO cells with an IC50 of 794.33 nM, and it inhibits human HDAC6 enzyme activity by 24.72% using a commercial peptide substrate. Furthermore, Tegobuvir demonstrates antiviral effects against SARS-CoV-2, inhibiting the virus-induced cytotoxicity of Caco-2 cells at 10 µM after 48 hours with an inhibition rate of 4.14%. It also inhibits SARS-CoV-2 3CL-Pro protease activity at 20 µM with inhibition percentages of 7.92% and 7.017%. However, inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells was relatively minimal, with percentages of 0.18% and -0.23%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.
Synonyms	GS-9190, GS 333126

Chemical Properties

Molecular Weight	517.4
Formula	C₂₅H₁₄F₇N₅
Cas No.	1000787-75-6
Smiles	Fc1ccccc1-c1nc2ccn(Cc3ccc(nn3)-c3ccc(cc3C(F)(F)F)C(F)(F)F)cc2n1
Relative Density.	1.46 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (96.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9327 mL	9.6637 mL	19.3274 mL	96.6370 mL
5 mM	0.3865 mL	1.9327 mL	3.8655 mL	19.3274 mL
10 mM	0.1933 mL	0.9664 mL	1.9327 mL	9.6637 mL
20 mM	0.0966 mL	0.4832 mL	0.9664 mL	4.8319 mL
50 mM	0.0387 mL	0.1933 mL	0.3865 mL	1.9327 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc