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NS6180

Name: NS6180
Brand: TargetMol
SKU: T1752
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1752Cas No. 353262-04-1

NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.

NS6180

🥰Excellent

Purity: 99.83%

Catalog No. T1752Cas No. 353262-04-1

NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.

Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$42	In Stock
5 mg	$64	In Stock
10 mg	$108	In Stock
25 mg	$236	In Stock
50 mg	$385	In Stock
100 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

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Purity:99.83%

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COA

Product Introduction

Bioactivity

Description	NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.
Targets&IC50	KCa3.1 channel:9 nM

Chemical Properties

Molecular Weight	323.33
Formula	C₁₆H₁₂F₃NOS
Cas No.	353262-04-1
Smiles	FC(F)(F)c1cccc(CN2C(=O)CSc3ccccc23)c1
Relative Density.	1.375 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (170.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0928 mL	15.4641 mL	30.9282 mL	154.6408 mL
5 mM	0.6186 mL	3.0928 mL	6.1856 mL	30.9282 mL
10 mM	0.3093 mL	1.5464 mL	3.0928 mL	15.4641 mL
20 mM	0.1546 mL	0.7732 mL	1.5464 mL	7.7320 mL
50 mM	0.0619 mL	0.3093 mL	0.6186 mL	3.0928 mL
100 mM	0.0309 mL	0.1546 mL	0.3093 mL	1.5464 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc