Grazoprevir hydrate

Name: Grazoprevir hydrate
Brand: TargetMol
SKU: T21456
Rating: 4.5 (1 reviews)

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Catalog No. T21456Cas No. 1350462-55-3

Alias MK-5172, MK5172, MK 5172, Grazoprevir

Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to most currently used antiviral medications.

Grazoprevir hydrate

😃Good

Catalog No. T21456Alias MK-5172, MK5172, MK 5172, GrazoprevirCas No. 1350462-55-3

Pack Size	Price	Availability
25 mg	Inquiry	1-2 weeks
50 mg	Inquiry	1-2 weeks
100 mg	Inquiry	1-2 weeks

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Product Introduction

Bioactivity

Description	Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to most currently used antiviral medications.
Targets&IC50	GT1a:0.01±0.01 nM (Ki), GT1b:0.01±<0.01 nM (Ki), GT2a:0.08±0.02 nM (Ki), GT2b:0.15±0.06 nM (Ki), GT3a:0.90±0.2 nM (Ki)
Synonyms	MK-5172, MK5172, MK 5172, Grazoprevir

Chemical Properties

Molecular Weight	784.92
Formula	C₃₈H₅₂N₆O₁₀S
Cas No.	1350462-55-3
Relative Density.	no data available

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble H2O: Insoluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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