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(S)-Thalidomide
🥰Excellent
Catalog No. T12644LCas No. 841-67-8
Alias (S)-(-)-Thalidomide
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma.
(S)-Thalidomide
🥰Excellent
Purity: 99.89%
Catalog No. T12644LAlias (S)-(-)-ThalidomideCas No. 841-67-8
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $56 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $313 | In Stock | |
| 100 mg | $562 | In Stock | |
| 500 mg | $1,190 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.89%
ee:96.80%
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Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma. |
| In vitro | In U266 cells cultured with (S)-Thalidomide, a decrease in cell viability (IC50: 362 μM) was observed, reflecting a significant increase in apoptosis (for example, on the 3rd day at 200 μM: 40.3+/-3.1% vs. 3.2+/-0.4% on the 0th day; P<0.001). Furthermore, the expression profile of genes involved in angiogenesis and apoptosis changed, with the most significant alterations observed in the expression of apoptosis-related genes[1]. |
| In vivo | Direct exposure of embryos to (S)-Thalidomide does indeed result in limb reduction defects in chick embryos. (S)-Thalidomide affects chick limb transplantation into host embryos in a dose-dependent manner. Moreover, S-thalidomide and S-EM12 are more teratogenic than R-thalidomide and R-EM12[2]. |
| Synonyms | (S)-(-)-Thalidomide |
| Molecular Weight | 258.23 |
| Formula | C13H10N2O4 |
| Cas No. | 841-67-8 |
| Smiles | O=C1N(C(=O)C=2C1=CC=CC2)[C@@H]3C(=O)NC(=O)CC3 |
| Relative Density. | 1.2944 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (232.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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