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L-Chicoric Acid

Name: L-Chicoric Acid
Brand: TargetMol
SKU: T6S2391
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6S2391Cas No. 70831-56-0

Alias trans-Caffeoyltartaric acid, dicaffeoyltartaric acid, Chicoric acid, (-)-Chicoric acid

L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.

L-Chicoric Acid

🥰Excellent

Purity: 99%

Catalog No. T6S2391Alias trans-Caffeoyltartaric acid, dicaffeoyltartaric acid, Chicoric acid, (-)-Chicoric acidCas No. 70831-56-0

Pack Size	Price	Availability
2 mg	$37	In Stock
5 mg	$59	In Stock
10 mg	$94	In Stock
25 mg	$157	In Stock
50 mg	$232	In Stock
100 mg	$345	In Stock
200 mg	$513	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Purity:99%

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Product Introduction

Bioactivity

Description	L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.
Targets&IC50	HIV-1 integrase:100 nM (IC50)
Synonyms	trans-Caffeoyltartaric acid, dicaffeoyltartaric acid, Chicoric acid, (-)-Chicoric acid

Chemical Properties

Molecular Weight	474.37
Formula	C₂₂H₁₈O₁₂
Cas No.	70831-56-0
Smiles	[C@H]([C@@H](OC(/C=C/C1=CC(O)=C(O)C=C1)=O)C(O)=O)(OC(/C=C/C2=CC(O)=C(O)C=C2)=O)C(O)=O
Relative Density.	1.641g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1081 mL	10.5403 mL	21.0806 mL	105.4030 mL
5 mM	0.4216 mL	2.1081 mL	4.2161 mL	21.0806 mL
10 mM	0.2108 mL	1.0540 mL	2.1081 mL	10.5403 mL
20 mM	0.1054 mL	0.5270 mL	1.0540 mL	5.2701 mL
50 mM	0.0422 mL	0.2108 mL	0.4216 mL	2.1081 mL
100 mM	0.0211 mL	0.1054 mL	0.2108 mL	1.0540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc