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GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated

GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated
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GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated

Catalog No. TMPK-00054
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 47.5 kDa and the accession number is Q9UNG2.
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Pack SizePriceAvailabilityQuantity
100 μg$8147-10 days
500 μg$3,2507-10 days
1 mg$5,4407-10 days
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Biological Description

Biological Information
Immobilized Human GITR, hFc Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human GITR Ligand Trimer, His Tag with the EC50 of 11.4ng/ml determined by ELISA.
Description
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 47.5 kDa and the accession number is Q9UNG2.
Species
Human
Expression System
HEK293 Cells
TagN-His-Flag
Accession NumberQ9UNG2
Synonyms
TL6,GITR Ligand,TNFSF18,AITRL,GITRL
Construction
Gln50-Ser177
Protein Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight47.5 kDa (predicted). Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Endotoxin< 1 EU/μg by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords