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YHO-13351 free base

Name: YHO-13351 free base
Brand: TargetMol
SKU: T13365
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13365Cas No. 912288-64-3

YHO-13351 free base, the water-soluble prodrug of YHO-13177, is an inhibitor of BCRP (breast cancer resistance protein).

YHO-13351 free base

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Purity: 99.89%

Catalog No. T13365Cas No. 912288-64-3

YHO-13351 free base, the water-soluble prodrug of YHO-13177, is an inhibitor of BCRP (breast cancer resistance protein).

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$106	In Stock
25 mg	$196	In Stock
50 mg	$313	In Stock
100 mg	$479	In Stock
500 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.89%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

YHO-13351 free base, the water-soluble prodrug of YHO-13177, is an inhibitor of BCRP (breast cancer resistance protein).

In vivo

In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of Irinotecan Hydrochloride with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas Irinotecan Hydrochloride alone had little effect in these tumor models[1].

Chemical Properties

Molecular Weight	483.62
Formula	C₂₆H₃₃N₃O₄S
Cas No.	912288-64-3
Smiles	CCN(CC)CC(=O)OC1CCN(CC1)c1ccc(\C=C(/C#N)c2ccc(OC)c(OC)c2)s1
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (186.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0677 mL	10.3387 mL	20.6774 mL	103.3870 mL
5 mM	0.4135 mL	2.0677 mL	4.1355 mL	20.6774 mL
10 mM	0.2068 mL	1.0339 mL	2.0677 mL	10.3387 mL
20 mM	0.1034 mL	0.5169 mL	1.0339 mL	5.1693 mL
50 mM	0.0414 mL	0.2068 mL	0.4135 mL	2.0677 mL
100 mM	0.0207 mL	0.1034 mL	0.2068 mL	1.0339 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc