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Ulixertinib hydrochloride

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Catalog No. T7005LCas No. 1956366-10-1

Ulixertinib hydrochloride (Ulixertinib HCl) is an orally available, selective and potent ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis, and may be used in the study of solid tumors.

Ulixertinib hydrochloride
Other Forms of Ulixertinib hydrochloride:
UlixertinibT7005869886-67-9
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Ulixertinib hydrochloride

🥰Excellent
Purity: 99.85%
Catalog No. T7005LCas No. 1956366-10-1
Ulixertinib hydrochloride (Ulixertinib HCl) is an orally available, selective and potent ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis, and may be used in the study of solid tumors.
Pack SizePriceAvailabilityQuantity
2 mg$35In Stock
5 mg$56In Stock
10 mg$89In Stock
25 mg$143In Stock
50 mg$198In Stock
100 mg$372In Stock
1 mL x 10 mM (in DMSO)$62In Stock
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Batch Information

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Purity:99.85%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Ulixertinib hydrochloride (Ulixertinib HCl) is an orally available, selective and potent ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis, and may be used in the study of solid tumors.
In vitro
Combined treatment with Ulixertinib hydrochloride and VS-5584 for 48 hours significantly induced cell death in human pancreatic adenocarcinoma (HPAC) cells from the PDAC cell lines BxPC-3, MIAPaCa-2 and CFPAC. [1]
In vivo
Ulixertinib hydrochloride potently inhibited neuroblastoma tumor growth and prolonged the overall survival of the treated mice in two different neuroblastoma mice models. [2]
Chemical Properties
Molecular Weight469.79
FormulaC21H23Cl3N4O2
Cas No.1956366-10-1
SmilesClC1=C(C=2C=C(C(N[C@H](CO)C3=CC(Cl)=CC=C3)=O)NC2)C=C(NC(C)C)N=C1.Cl
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 0.1 mg/mL(insoluble)
DMSO: 80 mg/mL (170.29 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1286 mL10.6431 mL21.2861 mL106.4305 mL
5 mM0.4257 mL2.1286 mL4.2572 mL21.2861 mL
10 mM0.2129 mL1.0643 mL2.1286 mL10.6431 mL
20 mM0.1064 mL0.5322 mL1.0643 mL5.3215 mL
50 mM0.0426 mL0.2129 mL0.4257 mL2.1286 mL
100 mM0.0213 mL0.1064 mL0.2129 mL1.0643 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

VRT-752271ERK2ERK1
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