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Ulixertinib hydrochloride

Name: Ulixertinib hydrochloride
Brand: TargetMol
SKU: T7005L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7005LCas No. 1956366-10-1

Ulixertinib hydrochloride (Ulixertinib HCl) is an orally available, selective and potent ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis, and may be used in the study of solid tumors.

Ulixertinib hydrochloride

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Purity: 99.85%

Catalog No. T7005LCas No. 1956366-10-1

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$372	-	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ulixertinib hydrochloride (Ulixertinib HCl) is an orally available, selective and potent ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis, and may be used in the study of solid tumors.
In vitro	Combined treatment with Ulixertinib hydrochloride and VS-5584 for 48 hours significantly induced cell death in human pancreatic adenocarcinoma (HPAC) cells from the PDAC cell lines BxPC-3, MIAPaCa-2 and CFPAC. [1]
In vivo	Ulixertinib hydrochloride potently inhibited neuroblastoma tumor growth and prolonged the overall survival of the treated mice in two different neuroblastoma mice models. [2]

Chemical Properties

Molecular Weight	469.79
Formula	C₂₁H₂₃Cl₃N₄O₂
Cas No.	1956366-10-1
Smiles	ClC1=C(C=2C=C(C(N[C@H](CO)C3=CC(Cl)=CC=C3)=O)NC2)C=C(NC(C)C)N=C1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL(insoluble)

DMSO: 80 mg/mL (170.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1286 mL	10.6431 mL	21.2861 mL	106.4305 mL
5 mM	0.4257 mL	2.1286 mL	4.2572 mL	21.2861 mL
10 mM	0.2129 mL	1.0643 mL	2.1286 mL	10.6431 mL
20 mM	0.1064 mL	0.5322 mL	1.0643 mL	5.3215 mL
50 mM	0.0426 mL	0.2129 mL	0.4257 mL	2.1286 mL
100 mM	0.0213 mL	0.1064 mL	0.2129 mL	1.0643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc