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AS-85

Name: AS-85
Brand: TargetMol
SKU: T39861
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39861Cas No. 2323623-80-7

Alias AS85

AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.

AS-85

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Purity: 98.96%

Catalog No. T39861Alias AS85Cas No. 2323623-80-7

AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	-	In Stock
5 mg	$413	7-10 days	7-10 days
10 mg	$689	7-10 days	7-10 days
25 mg	$1,490	7-10 days	7-10 days
50 mg	$2,380	7-10 days	7-10 days
100 mg	$3,790	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.96%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.
Targets&IC50	ASH1L histone methyltransferase:0.6 µM, SET domain of ASH1L:0.78 µM (Kd)
In vitro	AS-85 is a potent inhibitor of ASH1L histone methyltransferase with an IC50 of 0.6 µM and significant antileukemic activity.AS-85 binds tightly to the SET domain of ASH1L with a Kd value of 0.78 µM. AS-85 inhibits the proliferation of leukemia cells harboring different MLL1 translocations such as MV4;11, MOLM13 and KOPN8. AS-85 inhibited the proliferation of leukemia cells carrying different MLL1 translocations (e.g. MV4;11, MOLM13 and KOPN8) with GI50 values ranging from 5 µM to 25 µM, but did not have a significant effect on K562 leukemia cells without the MLL1 translocation. [1]
Synonyms	AS85

Chemical Properties

Molecular Weight	579.66
Formula	C₂₆H₂₈F₃N₅O₃S₂
Cas No.	2323623-80-7
Smiles	O=C(NCC=1C=CC=2C(=CN(C2C1)C3CCN(CC3)S(=O)(=O)C(F)(F)F)C=4C=CC=C(C4)C(=S)N)C5CNC5
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (138.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7251 mL	8.6257 mL	17.2515 mL	86.2575 mL
5 mM	0.3450 mL	1.7251 mL	3.4503 mL	17.2515 mL
10 mM	0.1725 mL	0.8626 mL	1.7251 mL	8.6257 mL
20 mM	0.0863 mL	0.4313 mL	0.8626 mL	4.3129 mL
50 mM	0.0345 mL	0.1725 mL	0.3450 mL	1.7251 mL
100 mM	0.0173 mL	0.0863 mL	0.1725 mL	0.8626 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc