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Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody
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Catalog No. TMAB-10930
Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAP3K7IP1 (Ser423). Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody
Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody
😃Good
Catalog No. TMAB-10930
Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAP3K7IP1 (Ser423). Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAP3K7IP1 (Ser423). Anti-Phospho-MAP3K7IP1 (Ser423) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human MAP3K7IP1 around the phosphorylation site of Ser423 |
| Antigen Species | Human |
| Gene Name | TAB1 |
| Gene ID | |
| Protein Name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
| Uniprot ID | |
| Function | May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. |
| Molecular Weight | Theoretical: 56 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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