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Phe-Lys(Trt)-PAB

🥰Excellent
Catalog No. T18540Cas No. 1116085-99-4

Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker used in the development of antibody-drug conjugates (ADCs), serving as a crucial component for releasing therapeutic agents within targeted cells.

Phe-Lys(Trt)-PAB

Phe-Lys(Trt)-PAB

🥰Excellent
Purity: 99.35%
Catalog No. T18540Cas No. 1116085-99-4
Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker used in the development of antibody-drug conjugates (ADCs), serving as a crucial component for releasing therapeutic agents within targeted cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$78In StockIn Stock
10 mg$113In StockIn Stock
25 mg$198In StockIn Stock
50 mg$293In StockIn Stock
100 mg$418In StockIn Stock
200 mg$598In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.35%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker used in the development of antibody-drug conjugates (ADCs), serving as a crucial component for releasing therapeutic agents within targeted cells.
In vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
Chemical Properties
Molecular Weight640.81
FormulaC41H44N4O3
Cas No.1116085-99-4
SmilesOCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O
Relative Density.1.195 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Phe-Lys(Trt)-PABPheLys(Trt)PABPhe Lys(Trt) PABInhibitorinhibitCleavableAntibody-drug conjugates linkersADCLinkerADC LinkersADC Linker
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