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CYP1B1-IN-3

Catalog No. T73039 CAS 2872575-51-2

CYP1B1-IN-3 is a potent, selective inhibitor of CYP1B1, exhibiting IC50 values of 6.6 nM for CYP1B1, 347.3 nM for CYP1A1, and <10000 nM for CYP1A2. It also impedes cell migration and invasion, and inhibits the P-gp, AKT/ERK, FAK/SRC, and EMT pathways [1].

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CYP1B1-IN-3, CAS 2872575-51-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	CYP1B1-IN-3 is a potent, selective inhibitor of CYP1B1, exhibiting IC50 values of 6.6 nM for CYP1B1, 347.3 nM for CYP1A1, and >10000 nM for CYP1A2. It also impedes cell migration and invasion, and inhibits the P-gp, AKT/ERK, FAK/SRC, and EMT pathways [1].
Targets&IC50	CYP1B1:6.6 nM, CYP1A1:347.3 nM, CYP1A2:>10000 nM
In vitro	CYP1B1-IN-3 (compound 77) at concentrations of 3.75-30.0 μM over 72 hours enhances the sensitivity of A549/Taxol cells to Taxol (0.06-1 μM) [1]. Additionally, at concentrations of 2.5, 5, and 10 μM, CYP1B1-IN-3 inhibits migration and invasion in both A549 and A549/Taxol cells [1]. Furthermore, CYP1B1-IN-3 at the same concentrations for 24 hours suppresses the AKT/ERK, FAK/SRC, and EMT pathways in A549/Taxol cells [1].

Molecular Weight	413.49
Formula	C20H16FN3O2S2
CAS No.	2872575-51-2

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

CYP1B1-IN-3 2872575-51-2 inhibitor inhibit

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