Ascochlorin

Name: Ascochlorin
Brand: TargetMol
SKU: T14330
Rating: 4.5 (1 reviews)

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Catalog No. T14330Cas No. 26166-39-2

Alias Ilicicolin D

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts anti-tumor properties by inhibiting the STAT3 signaling pathway, inducing apoptosis, and possessing anti-inflammatory activity[1][2][3].

Ascochlorin

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Catalog No. T14330Alias Ilicicolin DCas No. 26166-39-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$720	35 days	35 days
2500 μg	$2,860	35 days	35 days

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Product Introduction

Bioactivity

Description	Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts anti-tumor properties by inhibiting the STAT3 signaling pathway, inducing apoptosis, and possessing anti-inflammatory activity[1][2][3].
In vitro	Ascochlorin inhibits the mRNA expression and the protein secretion of interleukin (IL)-1β and IL-6 but not tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophage cells. Ascochlorin (Ilicicolin D) (10-50 μM; 24-72 hours) inhibits the viability of HepG2, HCCLM3 and Huh7 cells in a time and dose dependent manner[3]. Ascochlorin (1-50 μM) significantly suppresses the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreases the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Ascochlorin (50 μM; 48 hours) induces apoptosis in HCC cells[3]. Ascochlorin suppresses nuclear translocation and DNA binding affinity of nuclear factor-κB (NF-κB). Ascochlorin down-regulates phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and p-p38[2].
In vivo	Ascochlorin (Ilicicolin D) (2.5-5 mg/kg; i.p.; administered on specific days) inhibits tumor growth in an orthotopic HCC mouse model[1].
Synonyms	Ilicicolin D

Chemical Properties

Molecular Weight	404.93
Formula	C₂₃H₂₉ClO₄
Cas No.	26166-39-2
Smiles	C[C@@H]1CCC(=O)[C@H](C)[C@@]1(C)\C=C\C(\C)=C\Cc1c(O)c(Cl)c(C)c(C=O)c1O
Relative Density.	1.199g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc