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TC11

Name: TC11
Brand: TargetMol
SKU: T9083
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9083Cas No. 100823-03-8

Alias CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.

TC11

🥰Excellent

Purity: 97.86%

Catalog No. T9083Alias CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11Cas No. 100823-03-8

TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$58	In Stock
25 mg	$119	In Stock
50 mg	$197	In Stock
100 mg	$298	In Stock
200 mg	$433	In Stock

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Batch Information

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Purity:97.86%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
In vivo	TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.
Synonyms	CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

Chemical Properties

Molecular Weight	322.4
Formula	C₂₀H₂₂N₂O₂
Cas No.	100823-03-8
Smiles	CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(N)cc2C1=O
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (139.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1017 mL	15.5087 mL	31.0174 mL	155.0868 mL
5 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
10 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL
20 mM	0.1551 mL	0.7754 mL	1.5509 mL	7.7543 mL
50 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5509 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc