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DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $36 | - | In Stock | |
| 5 mg | $83 | - | In Stock | |
| 10 mg | $123 | - | In Stock | |
| 25 mg | $247 | - | In Stock | |
| 50 mg | $372 | - | In Stock | |
| 100 mg | $558 | - | In Stock |
| Description | DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions. |
| In vitro | ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker. |
| Molecular Weight | 674.74 |
| Formula | C36H42N4O9 |
| Cas No. | 1480516-75-3 |
| Smiles | O=C1C=CC(=O)N1CCC(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2 |
| Relative Density. | 1.31 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Viscous |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (59.28 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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