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L-DOPA methyl ester (hydrochloride)

🥰Excellent
Catalog No. T7654Cas No. 1421-65-4

L-DOPA methyl ester (LDME) is an agonist of dopamine D1 receptor.

L-DOPA methyl ester (hydrochloride)

L-DOPA methyl ester (hydrochloride)

🥰Excellent
Purity: 99.94%
Catalog No. T7654Cas No. 1421-65-4
L-DOPA methyl ester (LDME) is an agonist of dopamine D1 receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$44In StockIn Stock
500 mg$123In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.94%
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COA HNMR LCMS IC ORP

Product Introduction

Bioactivity
Description
L-DOPA methyl ester (LDME) is an agonist of dopamine D1 receptor.
In vitro
L-DOPA methyl ester (LDME) might ameliorate the functional cytoarchitecture in visual cortex area 17 through mechanisms that elevate DA content and increase endogenous c-fos expression, as well as inhibit neuronal lesion in visual cortex tissue
Chemical Properties
Molecular Weight247.675
FormulaC10H14ClNO4
Cas No.1421-65-4
SmilesCl.COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
Relative Density.1.322g/cm3
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 27.5 mg/mL (111.03 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (8.08 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0375 mL20.1877 mL40.3755 mL201.8775 mL
5 mM0.8075 mL4.0375 mL8.0751 mL40.3755 mL
10 mM0.4038 mL2.0188 mL4.0375 mL20.1877 mL
20 mM0.2019 mL1.0094 mL2.0188 mL10.0939 mL
50 mM0.0808 mL0.4038 mL0.8075 mL4.0375 mL
100 mM0.0404 mL0.2019 mL0.4038 mL2.0188 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LDOPA methyl ester (hydrochloride)L-DOPA methyl esterL DOPA methyl ester (hydrochloride)DopamineReceptorDopamine ReceptorD1
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